NORADRENERGIC PROJECTIONS TO THE VENTROMEDIAL HYPOTHALAMUS REGULATE FAT METABOLISM DURING ENDURANCE EXERCISE
NORADRENERGIC PROJECTIONS TO THE VENTROMEDIAL HYPOTHALAMUS REGULATE FAT METABOLISM DURING ENDURANCE EXERCISE
复制标题
DOI：
10.1016/j.neuroscience.2011.05.051
复制
发表时间：
2011-09-05
期刊：
影响因子：
3.3
通讯作者：
Inoue, K.
中科院分区：
文献类型：
--
作者：
Miyaki, T.;Fujikawa, T.;Inoue, K.
研究了耐力运动中中枢神经系统对能量代谢的调节作用。我们进行了呼吸气体分析功能麻痹腹内侧下丘脑（VMH），下丘脑外侧区，和室旁核的下丘脑与局部麻醉剂（利多卡因）在跑步机上运行的速度，允许有效的脂肪酸氧化。我们的研究结果表明，只有利多卡因治疗VMH衰减耐力运动过程中的脂肪酸氧化。在相同条件下，在大鼠体内微透析过程中，这些核的单胺能神经活动表明，在所有核中去甲肾上腺素的细胞外浓度显着增加。同样，运动过程中的某些时间点多巴胺显著增加，但无论运动与否，血清素浓度都没有变化。中断去甲肾上腺素能投射到VMH的6-羟基多巴胺衰减增强脂肪氧化在运行过程中。阻断剂治疗阐明了VMH的去甲肾上腺素能输入是由β-肾上腺素受体介导的。这些数据表明，有关外周组织状态的信息是通过起源于延髓，这可能是一个重要的贡献VMH及其下游机制，以增强脂肪酸氧化在运动过程中的去甲肾上腺素能投射。(C)2011年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The regulation of energy metabolism by the central nervous system during endurance exercise was examined. We conducted respiratory gas analysis by functionally paralyzing the ventromedial hypothalamus (VMH), the lateral hypothalamic area, and the paraventricular nucleus of the hypothalamus with local anaesthetic (lidocaine) during treadmill running at a velocity that allowed for efficient fatty acid oxidation. Our results showed that only the lidocaine treatment of the VMH attenuated fatty acid oxidation during endurance exercise. The monoaminergic neural activities at these nuclei during in vivo microdialysis in rats under the same conditions indicated a significant increase in the extracellular concentration of noradrenaline in all nuclei. Similarly, a significant increase in dopamine occurred at some points during exercise, but no change in serotonin concentration occurred regardless of exercise. Disruption of noradrenergic projections to the VMH by 6-hydroxydopamine attenuated the enhancement of fat oxidation during running. Blocker treatments clarified that noradrenergic inputs to the VMH are mediated by beta-adrenoceptors. These data indicate that information about peripheral tissues status is transmitted via noradrenergic projections originating in the medulla oblongata, which may be an important contribution by the VMH and its downstream mechanisms to enhanced fatty acid oxidation during exercise. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.