Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China
Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China
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DOI：
10.1016/s0304-3835(00)00643-1
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发表时间：
2001-01-26
期刊：
影响因子：
9.7
通讯作者：
Hainaut, P
中科院分区：
文献类型：
--
作者：
Guimaraes, DP;Lu, SH;Hainaut, P
我们分析了32名食管癌患者和57名食管癌细胞学正常的健康人的TP53密码子72多态性和HPV DNA，这些人来自中国食管癌高发地区（河南省林县）。脯氨酸等位基因在中国人群中的频率（0.63）明显高于大多数欧美人群。TP53密码子72基因型与肿瘤无显著相关性。我们还发现，在癌症病例和健康受试者中，HPV DNA的患病率均较低（6.7%）。我们的研究结果不支持食管癌高风险人群中食管癌、人乳头状瘤病毒感染风险与TP53密码子72多态性之间的关联。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
We analyzed TP53 codon 72 polymorphism, HPV DNA in 32 subjects with oesophageal cancer and 57 healthy subjects with normal oesophageal cytology from an area of China with a high prevalence for this cancer (Linxian County, Henan Province). The frequency of the proline allele (0.63) was significantly higher in the Chinese population than in most European or American populations. No significant association was found between TP53 codon 72 genotype and cancer. We also found a low prevalence of HPV DNA (6.7%) in both cancer cases and healthy subjects. Our findings do not support the association between risk of oesophageal cancer, human papilloma virus infection, and TP53 codon 72 polymorphism in a Chinese population at high risk of oesophageal cancer. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.