Explaining the causes of cell death in cyanobacteria: what role for asymmetric division?
Explaining the causes of cell death in cyanobacteria: what role for asymmetric division?
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DOI：
10.1093/plankt/fbt114
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发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Franklin, Daniel J.
中科院分区：
文献类型：
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作者：
Franklin, Daniel J.
蓝藻占全球初级生产量的很大一部分，因此具有重要的生态意义。单个蓝藻细胞有四种可能的命运：分裂，或许在休眠一段时间后，被吃掉，经历病毒裂解或经历细胞死亡。在一些研究中，蓝藻细胞死亡被归类为程序性细胞死亡，借用了后生动物细胞中更广为人知的概念，有各种生化上的相似之处来支持这种分类。然而，与此同时，人们越来越意识到不对称分裂是细菌分裂的基本过程，这可能导致不平等的子细胞具有不同的适应性。由于最近的理论和实验进展，现在有可能从不对称分裂的角度来探索蓝藻细胞的死亡，并检验关于蓝藻细胞死亡的最终原因的假说。评估种群增长过程中单个细胞内蛋白质损伤的程度是一个明智的初步研究目标，应用允许跟踪细胞谱系的技术也是如此。蓝藻中不对称分裂的存在很可能是因为它在生命的细菌领域中无处不在。从技术上讲，很难测试不对称分裂与环境变异性的相互作用，以及这如何通过对环境压力的不同敏感性导致单个细胞死亡。然而，测试这些想法可能证实不对称分裂是蓝藻细胞死亡的最终原因，从而允许更好地了解自然种群中细胞死亡的模式。
Cyanobacteria contribute a significant fraction of global primary production and are therefore of great ecological significance. An individual cyanobacteria cell has four potential fates: to divide, perhaps after a dormant period, to be eaten, to undergo viral lysis or to undergo cell death. In some studies, cyanobacteria cell death has been classified as programmed cell death, borrowing a concept more widely known in metazoan cells, and there are various biochemical parallels to support such a categorization. However, at the same time, there is a growing awareness of asymmetric division as a fundamental process in bacterial division which can result in non-equal daughter cells with differing fitness. Thanks to recent theoretical and experimental advances, it is now possible to explore cyanobacteria cell death in the light of asymmetric division and to test hypotheses on the ultimate causes of cyanobacterial cell death. Assessing the degree of protein damage within individual cells during population growth is a sensible initial research target as is the application of techniques which allow the tracking of cell lineages. The existence of asymmetric division in cyanobacteria is likely given its suggested ubiquity across the bacterial domain of life. It will be technically difficult to test the interaction of asymmetric division with environmental variability, and how that leads to individual cell death via differing susceptibilities to environmental stress. However, testing such ideas could confirm asymmetric division as the ultimate cause of cell death in cyanobacteria and thereby allow a better understanding of the patterns of cell death in natural populations.