The Blood Levels of Trace Elements Are Lower in Children With Tic Disorder: Results From a Retrospective Study
The Blood Levels of Trace Elements Are Lower in Children With Tic Disorder: Results From a Retrospective Study
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抽动症儿童的血液微量元素水平较低：回顾性研究结果
DOI：
10.3389/fneur.2019.01324
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发表时间：
2019-12-17
影响因子：
3.4
通讯作者：
Mao, Shanshan
中科院分区：
文献类型：
--
作者：
Qian, Ruiying;Ma, Ying;Mao, Shanshan
背景：抽动障碍(TD)是儿童和青少年常见的神经精神障碍。微量元素是否参与TD的发病机制尚存争议。本研究旨在了解TD患儿体内锌、铜、铁、镁等微量元素的状况，并与健康儿童进行比较。方法：回顾分析2018年1月1日至12月31日门诊符合条件的TD患儿和正常健康儿童的病历资料。收集所有受试者的临床资料，包括年龄、性别、诊断、既往健康记录，以及在开始治疗前诊断时的血清微量元素(铜、锌、铁、镁)水平。结果：共纳入1204名TD儿童(7.63+/-2.45岁)和1220名健康儿童(7.27+/-3.15岁)，按性别分为3个年龄组(2~4岁、5~9岁、10岁)。本研究显示TD儿童全血锌、铜、铁水平普遍低于正常对照组(P<；0.01)。全血镁水平无显著差异。在对性别进行调整后，这一趋势仍然存在。按年龄进行进一步分析，各年龄组锌、铁的变化趋势仍然存在(P<；0.05)。然而，我们观察到2~4年组儿童的铜水平几乎显著低于正常组(P=0.055)，而其他两组间差异有统计学意义(P<0.01)。进一步的多元线性回归和点双序列相关分析显示，血中锌、铜、铁水平越低，TD的发生率越高。结论：低锌、低铁、低铜水平与TD有关。微量元素可作为TD的辅助治疗手段，有待进一步探索。
Background: Tic disorders (TD) are common neuropsychiatric disorders among children and adolescents. It is controversial that trace elements may participate in the pathogenesis of TD. Our study aimed to investigate the trace elements status of zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) in children with TD, in comparison to healthy controls. Methods: The medical records of eligible TD children and normal healthy children from January 1 to December 31, 2018 in the outpatient clinic were retrospectively reviewed. The clinical information of all subjects were collected including age, gender, diagnosis, previous health records, and serum trace elements level (Cu, Zn, Fe, Mg) at the time of diagnosis before initiating treatment. Results: In total, 1204 TD children (7.63 +/- 2.45 years) and 1,220 healthy children (7.27 +/- 3.15 years) who were divided into two gender and three age groups (2-4years, 5-9years, >= 10 years) were reviewed in our study. Our study showed that TD children generally had lower whole blood levels of Zn, Cu, Fe than the normal controls (P < 0.01). No significant difference was observed in whole blood levels of Mg. After adjusting for gender, the trends still remained. Further analysis was performed according to age, the trends still remained in Zn and Fe in all age groups (P < 0.05). However, we observed an almost significantly (P = 0.055) lower level of Cu in TD of 2-4 years group while significant differences in other two groups (P < 0.01). Further multiple linear regression and point biserial correlation showed that the lower blood levels of Zn, Cu, and Fe were correlated with the incidence of TD. Conclusion: The present results indicated that lower blood levels of zinc, iron, copper were associated with TD. Trace elements may be used as an auxiliary treatment for TD and need to be further explored.