Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events.
Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events.
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DOI：
10.4049/jimmunol.148.4.1080
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发表时间：
1992-02
影响因子：
4.4
通讯作者：
M. Robinson;D. Andrew;H. Rosen;Derek Brown;S. Ortlepp;P. Stephens;E. Butcher
中科院分区：
文献类型：
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作者：
M. Robinson;D. Andrew;H. Rosen;Derek Brown;S. Ortlepp;P. Stephens;E. Butcher
粘附分子的白细胞细胞粘附分子（β 2整联蛋白）家族在正常免疫细胞功能所必需的细胞间粘附相互作用中起关键作用。在这项研究中，我们报告了一种抗体，它识别白细胞粘附分子共同β链（CD 18）上的表位，并促进淋巴细胞功能相关的Ag-1和CR 3依赖性粘附事件。该抗体识别不依赖于二价阳离子存在的温度敏感性表位。有人提出，抗体结合促进淋巴细胞功能相关的Ag-1和CR 3，这可能模拟自然的激活机制，导致细胞粘附增加的构象变化。
The Leukocytic cell-adhesion molecule (beta 2 integrin) family of adhesion molecules play a key role in the intercellular adhesive interactions necessary for normal immune cell function. In this study, we report an antibody that recognizes an epitope on the Leukocytic cell-adhesion molecule common beta-chain (CD18) and promotes both lymphocyte function-associated Ag-1- and CR3-dependent adhesion events. The antibody recognizes a temperature-sensitive epitope that is not dependent on the presence of divalent cations. It is proposed that antibody binding promotes a conformational change in both lymphocyte function-associated Ag-1 and CR3, which may mimic a natural activation mechanism, resulting in increased cellular adhesion.