Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity
Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity
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聚电解质吸附诱导的混合脂质膜的成分重新分布和动态异质性：链刚性的影响
DOI：
10.1140/epje/i2014-14071-8
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发表时间：
2014-08
影响因子：
1.8
通讯作者：
Huang Qingrong
中科院分区：
文献类型：
--
作者：
Zhang Ran;Shi Tongfei;An Lijia;Huang Qingrong
AbstractMonte Carlo simulation is employed to investigate the interaction between a polyelectrolyte and a fluid mixed membrane containing neutral (phosphatidyl-choline, PC), monovalent anionic (phosphatidylserine, PS), and multivalent anionic (phosphatidylinositol, PIP2) lipids. The effects of the intrinsic polyelectrolyte rigidity and solution ionic strength on the lateral rearrangement and dynamics of different anionic lipid species are systematically studied. Our results show that, the increase of polyelectrolyte chain rigidity reduces the loss of polyelectrolyte conformational entropy and the energy gains in electrostatic interaction, but raises the demixing entropy loss of the segregated anionic lipids. Therefore, the polyelectrolyte/membrane adsorption strength exhibits a non-monotonic dependence on the polyelectrolyte rigid parameterkang, and there exists a certain optimalkangfor which the adsorption strength is maximal. Because the less loss of chain conformational entropy dominates the increase of the demixing entropy loss of the segregated anionic lipids and the decreases of the electrostatic energy gains, the semiflexible polyelectrolyte adsorbs onto the membrane more firmly than the flexible one. Whereas, for the adsorption of rigid polyelectrolyte, larger anionic lipid demixing entropy loss and less energy gain in the electrostatic interaction dominate over the decrease of the polyelectrolyte conformation entropy loss, leading to the desorption of the chain from the membrane. By decreasing the ionic concentration of the salt solution, the certain optimalkangshifts to larger values. The cooperative effects of the adsorbing polyelectrolyte beads determine the concentration gradients and hierarchical mobility of the bound anionic lipids, as well as the polyelectrolyte dynamics.Graphical abstract
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影响因子：
3.9
作者：
M. Santin;W. Rhys-Williams;J. O’Reilly;M. Davies;K. Shakesheff;W. Love;A. Lloyd;S. Denyer
通讯作者：
M. Santin;W. Rhys-Williams;J. O’Reilly;M. Davies;K. Shakesheff;W. Love;A. Lloyd;S. Denyer
影响因子：
3.4
作者：
May, S;Harries, D;Ben-Shaul, A
通讯作者：
Ben-Shaul, A
影响因子：
--
作者：
D. Murray;A. Arbuzova;B. Honig;Stuart McLaughlint
通讯作者：
D. Murray;A. Arbuzova;B. Honig;Stuart McLaughlint
影响因子：
2.9
作者：
Cicchetti, G;Biernacki, M;Allen, PG
通讯作者：
Allen, PG
影响因子：
4.6
作者：
I. Porcar;Rosa García;C. Gómez;A. Campos;C. Abad
通讯作者：
I. Porcar;Rosa García;C. Gómez;A. Campos;C. Abad