Incompressible Biventricular Model Construction and Heart Segmentation of 4D Tagged MRI.
Incompressible Biventricular Model Construction and Heart Segmentation of 4D Tagged MRI.
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不可压缩双心室模型构建和 4D 标记 MRI 心脏分割。
DOI：
10.1007/978-1-4419-9619-0
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Axel,Leon
中科院分区：
文献类型：
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作者：
Montillo,Albert;Metaxas,Dimitris;Axel,Leon
图像引导的前列腺介入的准确性可以通过扭曲（即，非刚性配准）高质量多模态术前磁共振图像与术中前列腺几何形状。患者特异性生物力学模型已被应用在几项研究中预测前列腺术中变形的这种翘曲。获得关于应力参数的精确的患者特异性信息（例如，对于这样的模型，前列腺外周区（PZ）和中央腺（CG）的杨氏模量（杨氏模量）仍然是一个未解决的问题。在这项研究中，我们研究了10例前列腺近距离放射治疗中中央腺ECG与外周区EPZ的杨氏模量之比在预测前列腺术中变形时的影响。患者特定的前列腺模型的实施通过专门的非线性有限元程序，利用总拉格朗日公式和显式积分在时域。通过规定前列腺外表面的变形来定义载荷。采用neo-Hookean超弹性本构模型模拟PZ和CG力学响应。PZ与CG的杨氏模量比ECG：EPZ在1：1（文献数据的上限）和1：40（文献数据的下限）之间变化。该研究表明，预测的前列腺术中变形和结果的前列腺MRI非刚性配准获得使用预测的变形依赖于非常弱的心电图：EPZ比。
Accuracy of image-guided prostate interventions can be improved by warping (i.e., nonrigid registration) of high-quality multimodal preoperative magnetic resonance images to the intraoperative prostate geometry. Patient-specific biomechanical models have been applied in several studies when predicting the prostate intraoperative deformations for such warping. Obtaining exact patient-specific information about the stress parameter (e.g., Young’s modulus) of the prostate peripheral zone (PZ) and central gland (CG) for such models remains an unsolved problem. In this study, we investigated the effects of ratio of Young’s modulus of the central glandECGto the peripheral zoneEPZwhen predicting the prostate intraoperative deformation for ten cases of prostate brachytherapy. The patient-specific prostate models were implemented by means of the specialized nonlinear finite element procedures that utilize total Lagrangian formulation and explicit integration in time domain. The loading was defined by prescribing deformations on the prostate outer surface. The neo-Hookean hyperelastic constitutive model was applied to simulate the PZ and CG mechanical responses. The PZ to CG Young’s modulus ratioECG:EPZwas varied between 1:1 (upper bound of the literature data) and 1:40 (lower bound of the literature data). The study indicates that the predicted prostate intraoperative deformations and results of the prostate MRIs nonrigid registration obtained using the predicted deformations depend very weakly on theECG:EPZratio.