Frequency of nocturnal sudden death in patients with multiple system atrophy
Frequency of nocturnal sudden death in patients with multiple system atrophy
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DOI：
10.1007/s00415-008-0941-4
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发表时间：
2008-10-01
影响因子：
6
通讯作者：
Nishizawa, Masatoyo
中科院分区：
文献类型：
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作者：
Shimohata, Takayoshi;Ozawa, Tetsutaro;Nishizawa, Masatoyo
多系统萎缩（MSA）患者曾报告过猝死，但该事件的发生频率尚未明确。我们调查了MSA患者猝死的频率和潜在原因。在5年的观察期内，45例可能患有MSA的患者中有10例死亡。死亡原因包括不明原因的猝死（7例）、吸入性肺炎（1例）、呕吐后窒息（1例）和肺癌（1例）。猝死患者的平均生存时间为63.0 ± 24.7个月（范围，39-116个月）。在7名经历猝死的患者中，有6人在睡眠中死亡。在这些患者中，2例接受了气管切开术治疗，3例在睡眠期间接受了持续气道正压通气（CPAP）或无创正压通气（NPPV）治疗，这表明这些治疗并不总能预防MSA患者的猝死。夜间猝死是MSA患者最常见的死亡机制。
Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA. During the 5-year observation period, 10 of 45 patients with probable MSA died. The causes of death included sudden death of unknown etiology (seven patients), aspiration pneumonia (one patient), asphyxia after vomiting (one patient), and lung cancer (one patient). The mean survival time of patients with sudden death was 63.0 +/- 24.7 months (range, 39-116 months). Among seven patients who experienced sudden death, six were found to have died during sleep. Among these patients, two had been treated with tracheostomy and three with continuous positive airway pressure (CPAP) or noninvasive positive pressure ventilation (NPPV) during sleep, suggesting that these treatments do not always prevent sudden death in patients with MSA. Nocturnal sudden death should be recognized as the most common mechanism of death in patients with MSA.