WISE-2005: Exercise and Nutrition Countermeasures for Upright (V) over dotO2pk during Bed Rest
WISE-2005: Exercise and Nutrition Countermeasures for Upright (V) over dotO2pk during Bed Rest
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DOI：
10.1249/mss.0b013e3181aa04e5
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发表时间：
2009-12-01
期刊：
影响因子：
--
通讯作者：
Hargens, Alan R.
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文献类型：
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作者：
Schneider, Suzanne M.;Lee, Stuart M. C.;Hargens, Alan R.
SCHNEIDER, S. M., S. M. C. LEE, B. R. MACIAS, D. E. WATENPAUGH, and A. R. HARGENS. WISE-2005: Exercise and Nutrition Countermeasures for Upright (V) over dotO(2)pk during Bed Rest. Med. Sci. Sports Exerc., Vol. 41, No. 12, pp. 2165-2176, 2009. Purpose: Exercise prescriptions for spaceflight include aerobic and resistive countermeasures, yet few studies have evaluated their combined effects on exercise responses after real or simulated microgravity. We hypothesized that upright aerobic capacity ((V) over dotO(2)pk) is protected during a 60-d bed rest (BR) in which intermittent (40%-80% pre-BR (V) over dotO(2)pk) aerobic exercise (supine treadmill exercise against lower body negative pressure) was performed 2-4 d.wk(-1) and resistive exercise (inertial flywheel exercises) was performed 2-3 d.wk(-1). Further, we hypothesized that ingestion of an amino acid supplement that was shown previously to counteract muscle atrophy, would reduce the decline in (V) over dotO(2)pk in nonexercising subjects during BR. Methods: Twenty-four healthy women (8 nonexercise controls (CON), 8 exercisers (EX), and 8 nonexercisers with nutritional supplementation (NUT)) underwent a 20-d ambulatory baseline period, 60 d of 6 degrees head-down tilt BR, and 21 d of ambulatory recovery. (V) over dotO(2)pk was measured pre-BR and on the third day of recovery from BR (R3). Results: In the EX group, (V) over dotO(2)pk (mean +/- SE) was not different from pre-BR (-3.3 +/- 1.2%) on R3; although it decreased significantly in the CON (-21.2 +/- 2.1%) and NUT (-25.6 +/- 1.6%) groups. Conclusions: These results indicate that alternating aerobic and resistive exercise on most days during prolonged microgravity simulated by BR is sufficient to preserve or allow quick recovery of upright aerobic capacity in women but that a nutritional supplementation alone is not effective.
