Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment.
Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment.
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DOI：
10.1039/c4nr04864d
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发表时间：
2014-11
期刊：
影响因子：
6.7
通讯作者：
Weiwei Zhang;Yunqing Wang;Xiuyan Sun;Wenhai Wang;Lingxin Chen
中科院分区：
文献类型：
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作者：
Weiwei Zhang;Yunqing Wang;Xiuyan Sun;Wenhai Wang;Lingxin Chen
最近，表面增强拉曼散射(SERS)成像引导的热敏纳米平台引起了人们的极大关注。在这里，我们开发了新型蛋黄壳金纳米棒@空洞@介孔二氧化钛纳米颗粒(AUNR@空洞@mTiO2NPS)，用于同时进行₂成像和化学-光热治疗。我们的工作有三个突出的特点：第一，我们提出了一种简单、通用的自顶向下的表面增强拉曼光谱给药策略，该策略预先合成了“空载体”，然后依次将拉曼记者与抗癌药物阿霉素(DOX)共负载到mTiO-₂中。获得的SERS信号足以在活细胞和小鼠水平上追踪NPs。其次，我们选择了₂作为一种新型的载药材料，取代了广泛使用的介孔二氧化硅(mSiO-₂)。与mSiO-₂相比，mTiO-₂具有良好的载药和释药性能，但具有化学惰性。这一性质不仅提供了一种形成蛋黄-壳结构的简便方法，而且使其在生物系统中具有优异的结构稳定性。第三，还研究了AuNR SERS基质的近红外(NIR)光吸收性能，用于药物释放调节和光热处理。载DOX纳米粒子和近红外激光照射联合治疗时，MCF-7细胞的杀伤率显著提高，这归因于协同的化疗-热疗效应。我们的结果表明，所建立的SERS标记的蛋黄壳纳米粒是一种很有前途的治疗平台，并暗示了其在体内的潜在应用。
Recently surface-enhanced Raman scattering (SERS) imaging guided theranostic nanoplatforms have attracted considerable attention. Herein, we developed novel yolk-shell gold nanorod@void@mesoporous titania nanoparticles (AuNR@void@mTiO₂ NPs) for simultaneous SERS imaging and chemo-photothermal therapy. Our work showed three highlighted features: first, we proposed a facile and versatile "up to down" SERS labeling strategy for the drug delivery system, in which "empty carriers" were pre-synthesized, followed by co-loading of Raman reporters on AuNR and anti-cancer drug doxorubicin (DOX) in mTiO₂ in sequence. The acquired SERS signal was strong enough for tracking NPs at both living cells and mice levels. Second, we selected mTiO₂ as a novel drug loading material instead of the widely used mesoporous silica (mSiO₂). The mTiO₂ shared satisfactory drug loading and release behavior as mSiO₂ but it was chemically inert. This property not only provided a facile way to form a yolk-shell structure but also rendered it with superior structural stability in a biological system. Third, the near infrared (NIR) light absorbing property of the AuNR SERS substrate was also explored for drug release regulation and photothermal treatment. Significantly greater MCF-7 cell killing was observed when treated together with DOX-loaded NPs and NIR laser irradiation, attributable to the synergistic chemo-thermal therapeutic effect. Our results indicated the established SERS labeled yolk-shell NP as a promising theranostic platform and suggested its potential in vivo applications.