Inflammatory response after acute ischemic stroke
Inflammatory response after acute ischemic stroke
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DOI：
10.1016/j.jns.2005.05.006
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发表时间：
2005-09-15
影响因子：
4.4
通讯作者：
Grau, AJ
中科院分区：
文献类型：
--
作者：
Marquardt, L;Ruf, A;Grau, AJ
背景与目的：本研究旨在研究急性缺血性卒中后炎症指标的时程变化。方法：连续检测缺血性卒中后第1~90天10个时间点的高敏C反应蛋白(CRP)、纤维蛋白原和白细胞计数。结果：卒中后CRP无明显变化，而纤维蛋白原升高。在各时间点，C反应蛋白和纤维蛋白原均高于健康对照组，但不高于危险因素控制组。中风后白细胞计数下降，仅在第一天与两个对照组相比显着升高，而不是在以后。各时间点NIHSS水平与C反应蛋白、纤维蛋白原呈正相关。在第90天，较大的梗塞与较高的C反应蛋白和白细胞计数有关。阿司匹林治疗与脑缺血后亚急性期的三个炎症参数均较低有关。结论：卒中后的病程与炎症参数不同。只有白细胞遵循急性期反应的范例。(C)2005 Elsevier B.V.保留所有权利。
Background and purpose: This study aimed to characterize the time course of inflammatory parameters after acute ischemic stroke.Methods: We serially determined high sensitivity C-reactive protein (CRP), fibrinogen, and leukocyte counts at 10 time points between days I and 90 after ischemic stroke and in control subjects.Results: CRP did not significantly change, whereas fibrinogen increased after stroke. At all time points, CRP and fibrinogen were higher than in healthy control subjects, but not risk factor control subjects. The leukocyte count declined after stroke and was significantly elevated as compared to both control groups only on day 1 but not later. NIHSS levels were positively correlated with CRP and fibrinogen at all time points. Larger infarcts were associated with a higher CRP and leukocyte counts on day 90. Treatment with aspirin was associated with lower values for all three inflammatory parameters in the subacute phase after ischemia.Conclusions: The course after stroke was different between the parameters of inflammation. Only the leukocytes followed the paradigm of an acute phase response. (c) 2005 Elsevier B.V. All rights reserved.