Prostate cancer and microfluids
Prostate cancer and microfluids
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DOI：
10.1016/j.urolonc.2021.03.010
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发表时间：
2021-08-01
影响因子：
2.7
通讯作者：
Vasdev, Nikhil
中科院分区：
文献类型：
--
作者：
Bernstein, Darryl Ethan;Piedad, John;Vasdev, Nikhil
微流控系统的目标是在小范围内以高灵敏度和高分辨率快速检测样品物质。随着它在医学上的应用越来越多，该领域在前列腺癌诊断和治疗方面显示出巨大的希望，部分原因是它能够提供护理点检测。这篇综述重点介绍了前列腺癌和微流体方面的一些研究。本文首先对前列腺癌的微流控系统诊断进行了综述，并对前列腺癌特异性抗原、蛋白质和循环肿瘤细胞的检测进行了分析，以突出目前的研究进展。其次，本文分析了前列腺癌生理学的研究进展，并讨论了用于前列腺癌治疗的技术，如微环境的建立。最后，本综述强调了微流控技术在前列腺癌辅助治疗中的潜在作用，如体外分析。综上所述，这篇综述展示了微流控系统的广泛范围和应用，以及这些系统将如何确保未来前列腺癌治疗的进步。(C)爱思唯尔公司出版的《2021年》。
Microfluidic systems aim to detect sample matter quickly with high sensitivity and resolution, on a small scale. With its increased use in medicine, the field is showing significant promise in prostate cancer diagnosis and management due, in part, to its ability to offer point-ofcare testing. This review highlights some of the research that has been undertaken in respect of prostate cancer and microfluidics. Firstly, this review considers the diagnosis of prostate cancer through use of microfluidic systems and analyses the detection of prostate specific antigen, proteins, and circulating tumor cells to highlight the scope of current advancements.Secondly, this review analyses progressions in the understanding of prostate cancer physiology and considers techniques used to aid treatment of prostate cancer, such as the creation of a micro-environment.Finally, this review highlights potential future roles of microfluidics in assisting prostate cancer, such as in exosomal analysis. In conclusion, this review shows the vast scope and application of microfluidic systems and how these systems will ensure advancements to future prostate cancer management. (C) 2021 Published by Elsevier Inc.