Use-dependent behavioral and neurochemical asymmetry in MPTP mice
Use-dependent behavioral and neurochemical asymmetry in MPTP mice
复制标题
DOI：
10.1016/j.neulet.2006.03.045
复制
发表时间：
2007-05-18
影响因子：
2.5
通讯作者：
Miller, Gary W.
中科院分区：
文献类型：
--
作者：
Caudle, W. Michael;Tillerson, Jennifer L.;Miller, Gary W.
在帕金森病（PD）的早期，身体活动变得困难，导致更久坐的生活方式。临床和实验研究发现，纹状体多巴胺丢失后活动增加导致运动功能增加。PD早期体力活动减少沿着体力活动增加导致功能改善的发现向我们表明，在黑质纹状体变性期间体力活动减少可能不仅是损伤的症状，而且还可能促进变性。使用双侧MPTP小鼠PD模型，我们在注射后的前7天限制使用一只前肢。这种短暂的行为操纵期间的多巴胺退化导致了长期的赤字限制前肢。这表现为持续的不对称使用的前肢在壁勘探，以及纹状体半球之间的神经化学不平衡的多巴胺末端标记物的免疫反应性测量。DAT、VMAT2和TH。这些结果表明，行为和神经化学之间存在显著的相互作用，并表明活动水平的降低可能会进一步加剧退化。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
Early in Parkinson's disease (PD) physical activity becomes difficult resulting in a more sedentary lifestyle. Clinical and experimental studies have found that increased activity following striatal dopamine loss leads to increased motor function. Decreased physical activity early in PD along with findings that increased physical activity results in functional improvement suggested to us that decreased physical activity during the period of nigrostriatal degeneration may not only be a symptom of the injury, but may also act to potentiate the degeneration. Using the bilateral MPTP mouse model of PD, we restricted use of one forelimb for the first 7 days post-injection. This transient behavioral manipulation during the period of dopamine degeneration resulted in a long-lasting deficit of the restricted forelimb. This was manifested as sustained asymmetrical use of the forelimbs during wall exploration, as well as a neurochemical imbalance between striatal hemispheres measured by immunoreactivity of the dopamine terminal markers. DAT, VMAT2 and TH. These results show a significant interaction between behavior and neurochemistry and suggest that a reduction in activity level may further exacerbate degeneration. (C) 2006 Elsevier Ireland Ltd. All rights reserved.