EVOLUTION OF PROTEOLYTIC-ENZYMES
EVOLUTION OF PROTEOLYTIC-ENZYMES
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DOI：
10.1126/science.6369538
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
NEURATH, H
中科院分区：
文献类型：
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作者：
NEURATH, H
蛋白水解酶具有许多生理功能，从广义的蛋白质消化到更具体的调节过程，例如酶原的激活、血液凝固和纤维蛋白凝块的溶解、前体蛋白释放激素和药理活性肽以及跨膜运输分泌蛋白。它们存在于所有形式的生物体中。蛋白酶的氨基酸序列、三维结构和酶促反应机制的比较表明这些蛋白质存在不同的家族。分子结构和功能的变化伴随着蛋白水解酶及其抑制剂的进化，每种酶在原始生物中具有相对简单的作用，而在高等生物中具有更多样化和更复杂的功能。
Proteolytic enzymes have many physiological functions, ranging from generalized protein digestion to more specific regulated processes such as the activation of zymogens, blood coagulation and the lysis of fibrin clots, the release of hormones and pharmacologically active peptides from precursor proteins, and the transport of secretory proteins across membranes. They are present in all forms of living organisms. Comparisons of amino acid sequences, three-dimensional structures, and enzymatic reaction mechanisms of proteases indicate that there are distinct families of these proteins. Changes in molecular structure and function have accompanied the evolution of proteolytic enzymes and their inhibitors, each having relatively simple roles in primitive organisms and more diverse and more complex functions in higher organisms.