The theranostic nanoagent Mo2C for multi-modal imaging-guided cancer synergistic phototherapy
The theranostic nanoagent Mo2C for multi-modal imaging-guided cancer synergistic phototherapy
复制标题
用于多模态成像引导癌症协同光疗的治疗诊断纳米剂 Mo2C
DOI：
10.1039/c9bm00239a
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发表时间：
2019
影响因子：
6.6
通讯作者：
Guo Chongshen
中科院分区：
文献类型：
--
作者：
Zhang Qun;Huang Weicheng;Yang Chunyu;Wang Fei;Song Chuanqi;Gao Yan;Qiu Yunfeng;Yan Mei;Yang Bin;Guo Chongshen
多功能治疗平台，特别是基于单一成分的平台，既可以治疗癌症，也可以实时成像，并提高治疗效率。在这项研究中，50 nm的Mo2C纳米球被探索为一种“一劳永逸”的治疗药物。Mo2C的光捕获覆盖了整个近红外区，近红外辐射同时引发了高温和活性氧(ROS)的产生，从而实现了光热和光动力治疗的协同结果。体外和体内实验都证实了协同光疗在杀灭癌细胞和去除实体瘤方面的优越性；此外，本文提出的Mo2C已被证明可以作为光声成像和CT成像对比剂用于体内肿瘤的描绘；此外，Mo2C具有良好的生物相容性，表现出最小的血液毒性和组织毒性。用密度泛函理论进行的理论模拟表明，Mo2C的金属特性和带间/带内跃迁是其广泛光吸收的原因。通过B型超声(US)和核磁共振成像(MRI)研究了Mo2C在实体瘤上的抗肿瘤机制，显示了典型的液化坏死过程，因此，双成像引导的光疗是由Mo2C有效地介导的。
Multifunctional theranostic platforms, especially single component-based platforms, enable both cancer treatment and real-time imaging as well as enhance the efficiency of treatment. In this study, 50 nm Mo2C nanospheres were explored as a “one-for-all” theranostic agent. The light-harvesting of Mo2C covered the entire near infrared region, and NIR irradiation concurrently triggered hyperthermia and reactive oxygen species (ROS) production; thus, synergistic outcomes of photothermal and photodynamic therapy could be realized. Both in vitro and in vivo experiments have confirmed the superiority of the synergistic phototherapy in killing cancer cells and removing solid tumors; moreover, Mo2C proposed herein has been proven to be applicable as a photoacoustic imaging and CT imaging contrast agent for in vivo tumor depiction; furthermore, Mo2C demonstrates excellent biocompatibility, showing minimal hematotoxicity and tissue toxicity. A theoretical simulation performed by density functional theory revealed that the metallic character and the interband/intraband transition of Mo2C accounted for its broad photoabsorption. The antitumor mechanism of Mo2C was investigated on a solid tumor by B-mode ultrasonography (US) and magnetic resonance imaging (MRI), revealing a typical liquefactive necrosis process; hence, herein, the dual-imaging guided phototherapy was efficiently mediated by Mo2C.