From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.
From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.
复制标题
DOI：
10.1016/j.ceb.2020.01.004
复制
发表时间：
2020-02
影响因子：
7.5
通讯作者：
Coralie Trentesaux;Katharine Striedinger;J. Pomerantz;O. Klein
中科院分区：
文献类型：
--
作者：
Coralie Trentesaux;Katharine Striedinger;J. Pomerantz;O. Klein
Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states.
