Higher Contents of Mineral and Collagen but Lower of Hydroxylysine of Collagen in Mandibular Bone Compared with Those of Humeral and Femoral Bones in Human
Higher Contents of Mineral and Collagen but Lower of Hydroxylysine of Collagen in Mandibular Bone Compared with Those of Humeral and Femoral Bones in Human
复制标题
与人体肱骨、股骨相比，下颌骨矿物质和胶原蛋白含量较高，但胶原蛋白羟赖氨酸含量较低
DOI：
10.2485/jhtb.19.175
复制
发表时间：
2010
影响因子：
0.4
通讯作者：
Hironobu Sato
中科院分区：
文献类型：
--
作者：
Michiko Sasaki;T. Matsuura;Michitsuna Katafuchi;Kentaro Tokutomi;Hironobu Sato
矿物质和胶原蛋白是骨骼的主要成分。目前，与身体的其他骨骼相比，对颌骨的材料特性知之甚少。本研究的目的是表征下颌骨的材料特性表示的矿物质，胶原蛋白和羟赖氨酸（Hyl）的量相比，肱骨和股骨使用人尸体。下颌骨中的矿物质和胶原含量显著高于肱骨和股骨，但下颌骨中的Hyl显著低于肱骨和股骨。在三个指标中，胶原蛋白和矿物质含量之间存在弱但显著的正相关关系。Hyl与骨矿物质呈弱但显著负相关，年龄、性别和牙齿状况对Hyl的影响不大。这些结果表明，人下颌骨的材料特性与肱骨和股骨不同，并且可能具有更高的机械性能，这可以通过以下假设来解释：胶原蛋白的赖氨酸羟基化程度足够且没有过度导致最佳的胶原原纤维形成和基质矿化。本研究中所示的骨特性评估可能揭示无法通过骨量表达的未知特征。
Minerals and collagen are major components of bone. At present, little is known about the material property of the jaw bone compared to other bones of the body. The purpose of this study was to characterize the material property of mandibular bone expressed by the amount of mineral, collagen, and hydroxylysine (Hyl) in comparison with humeral and femoral bones using human cadavers. Mineral and collagen contents were significantly higher in the mandible than in humerus and femur but Hyl was significantly lower in the mandible. Among the three indices, a weak but significantly positive correlation between collagen and mineral contents was observed. On the contrary, Hyl showed a weak but significantly negative correlation with mineral. The three indices were almost not affected by aging, gender, and dental status which were thought to influence bone quantity. These results suggest that human mandibular bone differs in material property from humeral and femoral bones, and may possess a higher mechanical property explained by the hypothesis that adequate and no excessive extent of lysine hydroxylation of collagen leads to optimal collagen fibrillogenesis and matrix mineralization. The assessment of bone property as shown in this study could disclose unknown characteristics which cannot be expressed by bone quantity.
影响因子：
2.9
作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic
通讯作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic