Protein kinase C activity as marker for colorectal cancer
Protein kinase C activity as marker for colorectal cancer
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蛋白激酶 C 活性作为结直肠癌的标志物
DOI：
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发表时间：
1991
影响因子：
6.4
通讯作者：
Joji Utsunomiya
中科院分区：
文献类型：
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作者：
Y. Sakanoue;T. Hatada;M. Kusunoki;H. Yanagi;T. Yamamura;Joji Utsunomiya
蛋白激酶C （PKC）活性在结肠切除术患者正常结肠黏膜中被测量。对结直肠癌患者和非结直肠癌患者进行了比较。结直肠癌患者细胞质和颗粒部分PKC活性显著降低，分别为40±9 （pmol/min/mg）和114±29 (pmol/min/mg)；129±11和250±38 (pmol/min/mg) （p < 0.05）。与非肿瘤患者相比，肿瘤患者正常结肠黏膜细胞浆和颗粒部分PKC总活性明显降低（10±1和20±3比30±2和33±6）（pmol/min/g组织）（p < 0.05）。肿瘤患者（64%）的PKC活性在正常粘膜中的细胞分布（百分比颗粒分数）高于非肿瘤患者（49%）（p < 0.05）。我们的数据表明PKC活性可能被用作发生结直肠癌风险或无症状肿瘤风险的生物学标志物。
Protein kinase C (PKC) activity was measured in normal‐appearing colonic mucosa from patients undergoing colonic resection. Comparisons were made between cases with and without colorectal cancers. PKC activity in cytosolic and particulate fractions was significantly reduced in patients with colorectal cancer: 40 ± 9 and 114 ± 29 (pmol/min/mg) respectively, compared with patients without cancer; 129 ± 11 and 250 ± 38 (pmol/min/mg) (p < 0.05). Normal‐appearing colonic mucosa in patients with cancer showed significantly decreased total PKC activities in the cytosolic and particulate fractions compared with those In patients without cancer (10 ± I and 20 ± 3 vs. 30 ± 2 and 33 ± 6) (pmol/min/g tissue) (p < 0.05). The cellular distribution (% particulate fraction) of PKC activity in normal‐appearing mucosa in patients with cancer (64%) was higher than in patients without cancer (49%) (p < 0.05). Our data suggest that PKC activity may be used as a biological marker of risk of developing colorectal cancer or risk of bearing an asymptomatic tumor.
不同增殖活性的大鼠结肠上皮细胞中蛋白激酶C的亚细胞分布。
影响因子：
11.2
作者：
Craven,PA;DeRubertis,FR
通讯作者：
DeRubertis,FR
人类结肠癌中蛋白激酶 C 和 Ca2 依赖性蛋白激酶的水平发生改变。
影响因子：
11.2
作者：
Guillem,JG;O'Brian,CA;Fitzer,CJ;Forde,KA;LoGerfo,P;Treat,M;Weinstein,IB
通讯作者：
Weinstein,IB
1,2-二甲基肼诱导大鼠癌前结肠中蛋白激酶 C 活性的改变。
影响因子：
11.2
作者：
Baum,CL;Wali,RK;Sitrin,MD;Bolt,MJ;Brasitus,TA
通讯作者：
Brasitus,TA