Genetics and phenotyping in chronic sinusitis
Genetics and phenotyping in chronic sinusitis
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DOI：
10.1016/j.jaci.2011.05.022
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发表时间：
2011-10-01
影响因子：
14.2
通讯作者：
Steinke, John W.
中科院分区：
文献类型：
--
作者：
Payne, Spencer C.;Borish, Larry;Steinke, John W.
慢性鼻窦炎伴鼻息肉病历来被视为单一的整体临床疾病。就像哮喘现在被认为是许多异质性疾病一样，慢性鼻窦炎也应该被视为包括几种不同原因的疾病，每种疾病的特征在于不同的组织学和基因及蛋白质表达模式。这包括认识到需要根据嗜酸性粒细胞浸润的存在或不存在来定义这些疾病，但也需要根据驱动其发展和延续的独特因子来进行额外的区分。作为异质性疾病的集合，需要适当的鉴别诊断来描述适当的治疗干预。本综述将重点介绍慢性鼻窦疾病的公认的不同表现，包括区分临床表现，细胞和分子特征，遗传差异，以及目前的治疗方案。（J Allergy Clin Immunol 2011;128：710-20.）
Chronic sinusitis with nasal polyposis historically has been treated as a single monolithic clinical disorder. Just as asthma is now accepted as numerous heterogeneous diseases, chronic sinusitis should also be viewed as comprising several diseases with varying causes, with each one characterized by distinct histologic and gene and protein expression patterns. This includes recognition of the need to define these diseases based on the presence or absence of an eosinophilic infiltrate but also on additional distinctions based on unique agents that drive their development and perpetuation. As a collection of heterogeneous diseases, proper differential diagnosis is required to delineate appropriate therapeutic intervention. This review will focus on recognized distinct presentations of chronic sinus disease, including distinguishing the clinical presentations, cellular and molecular characteristics, genetic differences, and current treatment options for each. (J Allergy Clin Immunol 2011;128:710-20.)