Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast
Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast
复制标题
美国墨西哥湾沿岸神秘濒临灭绝的红狼基因组祖先的持续存在和扩张
DOI：
10.1111/mec.16200
复制
发表时间：
2021
影响因子：
4.9
通讯作者：
Murphy, William J.
中科院分区：
文献类型：
--
作者：
vonHoldt, Bridgett M.;Brzeski, Kristin E.;Aardema, Matthew L.;Schell, Christopher J.;Rutledge, Linda Y.;Fain, Steven R.;Shutt, Amy C.;Linderholm, Anna;Murphy, William J.
混合和渗入在适应和遗传拯救中发挥着关键作用，直到最近才得到更深入的认识。在这里，我们探索了濒危红狼的神秘祖先的地理和基因组景观，这些红狼存在于一个无处不在的姐妹分类群土狼的基因组中，而自20世纪80年代初以来，红狼已经在野外灭绝。我们评估了293个犬科动物基因组中120，621个单核苷酸多态性（SNP）基因座的混合物。我们发现支持增加红狼祖先沿着西向东梯度横跨美国南部与历史混合在过去的100年。路易斯安那州西南部和得克萨斯州东南部是最后一批红狼在野外灭绝之前已知的地理区域，包含了最高和最古老的红狼祖先。此外，由于缺乏基于染色体类型的推断，我们比较了X染色体和常染色体上的祖先模式。此外，我们的目的是探索混合时间和重组率变化之间的关系，以调查基因流事件。我们发现，相对于常染色体，低重组率的X连锁区域缺乏渐渗，这与大X效应和参与维持生殖隔离的基因座富集一致。在土狼基因组中，繁殖率与红狼血统呈正相关，与理论预测一致。神秘的红狼祖先的地理和基因组范围可以为针对濒危红狼保护的恢复计划提供新的基因组资源。
Admixture and introgression play a critical role in adaptation and genetic rescue that has only recently gained a deeper appreciation. Here, we explored the geographical and genomic landscape of cryptic ancestry of the endangered red wolf that persists within the genome of a ubiquitous sister taxon, the coyote, all while the red wolf has been extinct in the wild since the early 1980s. We assessed admixture across 120,621 single nucleotiode polymorphism (SNP) loci genotyped in 293 canid genomes. We found support for increased red wolf ancestry along a west‐to‐east gradient across the southern United States associated with historical admixture in the past 100 years. Southwestern Louisiana and southeastern Texas, the geographical zone where the last red wolves were known prior to extinction in the wild, contained the highest and oldest levels of red wolf ancestry. Further, given the paucity of inferences based on chromosome types, we compared patterns of ancestry on the X chromosome and autosomes. We additionally aimed to explore the relationship between admixture timing and recombination rate variation to investigate gene flow events. We found that X‐linked regions of low recombination rates were depleted of introgression, relative to the autosomes, consistent with the large X effect and enrichment with loci involved in maintaining reproductive isolation. Recombination rate was positively correlated with red wolf ancestry across coyote genomes, consistent with theoretical predictions. The geographical and genomic extent of cryptic red wolf ancestry can provide novel genomic resources for recovery plans targeting the conservation of the endangered red wolf.
登录
查看更多内容
人口统计历史影响最近扩张的郊狼（Canis latrans）种群遗传多样性的空间模式
影响因子：
3.8
作者：
Elizabeth Heppenheimer;Daniela S. Cosio;Kristin E. Brzeski;Danny Caudill;Kyle Van Why;Michael J. Chamberlain;Joseph W. Hinton;B. Vonholdt
通讯作者：
B. Vonholdt
最近在德克萨斯州东部收集的犬科动物，以及对红狼分类学的评论
DOI：
--
发表时间：
1968
期刊：
影响因子：
--
作者：
J. Paradiso
通讯作者：
J. Paradiso
影响因子：
6.3
作者：
J. Kronenberger;Jill C. Gerberich;S. Fitzpatrick;E. D. Broder;L. Angeloni;W. C. Funk
通讯作者：
W. C. Funk
影响因子：
3.1
作者：
Heppenheimer, Elizabeth;Brzeski, Kristin E.;vonHoldt, Bridgett M.
通讯作者：
vonHoldt, Bridgett M.
影响因子：
4.9
作者：
Harrison RG;Larson EL
通讯作者：
Larson EL