E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7
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DOI：
10.1038/sj.onc.1208703
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发表时间：
2005-07-21
期刊：
影响因子：
8
通讯作者：
La Thangue, NB
中科院分区：
文献类型：
--
作者：
Logan, N;Graham, A;La Thangue, NB
E2F是一个涉及细胞周期控制的转录因子家族。为了理解E2F在控制细胞周期进程中的作用，有必要澄清E2F家族的广度。迄今为止，已经确定了7个E2F亚基。我们在这里报告了一个新的E2F亚基E2F-8的特征，它类似于E2F-7的两个独立的DNA结合域的存在，其完整性是E2F-8与DNA结合所必需的。此外，与E2F-7一样，我们发现E2F-8可以抑制转录并延缓细胞周期进程。E2F-7和E2F-8之间的相似性定义了E2F家族的一个新亚群，并进一步表明E2F-7和E2F-8可能通过重叠机制介导细胞周期控制。
E2F is a family of transcription factors implicated in cell cycle control. To understand the role of E2F in controlling cell cycle progression, it is necessary to clarify the breadth of the E2F family. To date, seven E2F subunits have been identified. We report here the characterization of a new E2F subunit, E2F-8, which resembles the organization of E2F-7 in the presence of two separate DNA-binding domains, the integrity of which is required for E2F-8 to bind to DNA. Furthermore, like E2F-7, we find that E2F-8 can repress transcription and delay cell cycle progression. The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.