Serum dioxin concentrations and menstrual cycle characteristics
Serum dioxin concentrations and menstrual cycle characteristics
复制标题
DOI：
10.1093/aje/kwf046
复制
发表时间：
2002-08-15
影响因子：
5
通讯作者：
Olive, D
中科院分区：
文献类型：
--
作者：
Eskenazi, B;Warner, M;Olive, D
2，3，7，8-四氯二苯并二恶英（TCDD）是一种广泛存在的工业环境污染物。动物研究表明，TCDD暴露会改变发情周期。在1976年意大利塞维索工业爆炸20年后，作者采访了女性居民，以确定TCDD暴露与当前月经周期特征之间是否存在关联。作者分析了爆炸后不久收集的血清样本，以量化个体TCDD水平。在爆发时处于月经前期的妇女中，血清TCDD水平增加10倍与月经周期延长0.93天（95%置信区间（CI）：-0.01，1.86）和月经量不足的几率降低（校正比值比= 0.33，95%CI：0.10，1.06）相关。然而，在月经初潮后爆发的女性中，TCDD与月经周期长度（调整后的β = -0.03天，95% CI：-0.61，0.54）或流量不足（调整后的比值比= 1.36，95% CI：0.70，2.64）无关。在两个初潮组中，TCDD水平与不规则月经周期的几率降低相关（调整后的比值比= 0.46，95% CI：0.23，0.95），但与血流天数无关（调整后的P = 0.16天，95% CI：-0.08，0.41）。这些结果与在某些动物物种中观察到的TCDD对卵巢功能的影响一致，并且在发育过程中对TCDD更敏感。
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread industrial environmental contaminant. Animal studies suggest that TCDD exposure alters the estrus cycle. Twenty years after a 1976 industrial explosion in Seveso, Italy, the authors interviewed female residents to determine whether there was an association between TCDD exposure and current menstrual cycle characteristics. The authors analyzed serum samples collected soon after the explosion to quantify individual TCDD levels. Among women who were premenarcheal at the time of the explosion, a 10-fold increase in serum TCDD level was associated with a lengthening of the menstrual cycle by 0.93 days (95% confidence interval (Cl): -0.01, 1.86) and a reduction in the odds of scanty menstrual flow (adjusted odds ratio = 0.33, 95% Cl: 0.10, 1.06). However, among women who were postmenarcheal at the time of the explosion, TCDD was not associated with menstrual cycle length (adjusted beta = -0.03 days, 95% Cl: -0.61, 0.54) or scantiness of flow (adjusted odds ratio = 1.36, 95% Cl: 0.70, 2.64). In both menarche groups, TCDD levels were associated with decreased odds of having irregular cycles (adjusted odds ratio = 0.46, 95% Cl: 0.23, 0.95) but were not related to days of flow (adjusted P = 0.16 days, 95% Cl: -0.08, 0.41). These results are consistent with effects of TCDD on ovarian function noted in some animal species and with greater sensitivity to TCDD during development.