Increased permeability of a glial blood-brain barrier during acute hyperosmotic stress.
Increased permeability of a glial blood-brain barrier during acute hyperosmotic stress.
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急性高渗应激期间神经胶质血脑屏障的通透性增加。
DOI：
10.1152/ajpregu.1986.251.6.r1186
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Cserr,HF
中科院分区：
文献类型：
--
作者：
Mackie,K;DePasquale,M;Cserr,HF
基于渗透调节剂（包括钠、氯和钾）的增加，在小冰鞋（Raja erinacea）的急性高钠血症期间调节脑容量[Cserr等人，Am. J.Physiol.245（Regulatory Integrative Comp.Physiol.14）：R853-R859，1983]。在这项研究中，我们表明，这种容量调节反应是在35分钟内完成，并检查在此期间通过血脑屏障的钠流入的机制。溜冰鞋有神经胶质血脑屏障使用[Ohno et al.Am.生理学杂志。235（心脏循环。4）：H299-H307，1978]。在冰鞋肌肉注射等渗盐水（对照）或高渗NaCl或果糖，K1钠与渗透压线性增加。这种增加与高钠血症和果糖诱导的高渗性相同，并且不受“袢”利尿剂布美他尼的影响。甘露醇的K1也随渗透压摩尔浓度增加。这些结果表明，高渗增加屏障通透性的非选择性机制。利用血浆-脑交换的扩散模型评估急性高钠血症期间血脑屏障内流对组织钠获得的贡献。
Brain volume is regulated during acute hypernatremia in the little skate, Raja erinacea, based on the gain of osmolytes, including sodium, chloride, and potassium [Cserr et al., Am. J. Physiol. 245 (Regulatory Integrative Comp. Physiol. 14): R853-R859, 1983]. In this study we show that this volume regulatory response is complete in 35 min and examine the mechanism of sodium influx across the blood-brain barrier over this period. Skates have a glial blood-brain barrier. Blood-to-brain transfer constants (K1) for 22Na and [14C]mannitol were measured using the integral technique of [Ohno et al.Am. J. Physiol. 235 (Heart Circ. Physiol. 4): H299-H307, 1978]. In skates injected intramuscularly with isotonic saline (controls) or with hypertonic NaCl or fructose, K1 for sodium increased linearly with osmolality. This increase was the same for hypernatremia and fructose-induced hypertonicity, and it was not affected by the “loop” diuretic bumetanide. K1 for mannitol also increased with osmolality. These results suggest that hypertonicity increases barrier permeability by a nonselective mechanism. The contribution of influx across the blood-brain barrier to tissue sodium gain during acute hypernatremia is assessed using a diffusional model of plasma-brain exchange.