Triterpenoid Acids from Eriobotrya japonica
Triterpenoid Acids from Eriobotrya japonica
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DOI：
10.1007/s10600-019-02645-3
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发表时间：
2019-01
影响因子：
0.8
通讯作者：
Xin Wei;D. Song;Hong-Tao Zhu;Hao-fei Yu;C. Ding;Min Xu;Ying-Jun Zhang
中科院分区：
文献类型：
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作者：
Xin Wei;D. Song;Hong-Tao Zhu;Hao-fei Yu;C. Ding;Min Xu;Ying-Jun Zhang
枇杷（Eriobotrya japonica（Thunb.）Lindl.（蔷薇科）是公认的治疗各种皮肤病和糖尿病的传统中药。本文报道了E. japonica的主要次生代谢产物为三萜类化合物，包括三萜酸[1]。我们前期的研究表明三萜酸类化合物可以降低皮层锥体神经元的兴奋性，并在癫痫中起作用[2]。在我们正在进行的寻找新的和生物活性的三萜酸，详细的化学研究E。japonica进行。通过波谱分析，共分离鉴定了13个三萜酸类化合物，其中化合物1、2和4分别从E.首次报道了粳稻。将E.用甲醇（50 L× 3）在70 ℃下回流提取，每次3 h。在减压下除去有机溶剂后，将萃取物（1.0 kg）悬浮在H2O中，
The leaves of Eriobotrya japonica (Thunb.) Lindl.(Rosaceae) were commonly recognized as a traditional Chinese medicine (TCM) to treat various skin diseases and diabetes mellitus. Phytochemical investigations on the leaves of E. japonica revealed their predominant secondary metabolites as triterpenoids including triterpenoid acids [1]. Our previous study showed that triterpenoid acids can decrease the excitability of cortical pyramidal neurons and acts in epilepsy [2]. In our ongoing search for novel and bioactive triterpenoid acids, a detail chemical investigation on the dried leaves of E. japonica was carried out. As a result, 13 triterpenoid acids were isolated and identified on the basis of extensive spectral methods, among which compounds 1, 2, and 4 were isolated from E. japonica for the first time. The air-dried and powdered leaves of E. japonica (10.0 kg) were extracted with MeOH (50 L× 3) under reflux conditions at 70 C, three hours each time. After removal of the organic solvent under reduced pressure, the extract (1.0 kg) was suspended in H