FLUORIDE PHARMACOKINETICS IN INFANCY
FLUORIDE PHARMACOKINETICS IN INFANCY
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DOI：
10.1203/00006450-199402000-00006
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发表时间：
1994-02-01
影响因子：
3.6
通讯作者：
NELSON, SE
中科院分区：
文献类型：
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作者：
EKSTRAND, J;FOMON, SJ;NELSON, SE
提供了给予氟化物补充剂的婴儿的氟化物药代动力学数据。 17 名婴儿参与了总共 20 项研究。有一天，给予 0.013 mmol（0.25 mg）氟化物作为补充剂（氟化物补充剂研究），另一天给予安慰剂（对照研究）。收集血浆和尿液样本 5 小时并分析氟化物。在对照研究期间，氟化物摄入量平均为0.15μmol/kg（2.9μg/kg），血浆氟化物浓度范围为0.05至0.11μmol/L（10至20μg/L）。在九个案例中，尿液中排出的氟化物量是消耗量的两倍多。当补充氟化物时，总氟化物摄入量平均为1.93μmol/kg（36.6μg/kg）。 14 项研究中血浆峰值浓度在 30 分钟内达到峰值浓度，6 项研究中则在 60 分钟内达到血浆峰值浓度。平均血浆峰值氟化物浓度为 3.3 μmol/L (63 ng/mL)。血浆浓度曲线下面积平均为236 nmol.m(-1).min (4479 ng.mL(-1).min)，与氟化物剂量无关。尿排泄率与尿流量显着相关。当氟化物剂量以每单位体重表示时，氟化物滞留与剂量密切相关。从氟化物剂量中吸收的氟化物的保留范围为 75.4% 至 87.6%。血浆清除率平均为6.8 mL.kg(-1).min(-1)，并随着年龄的增长而显着下降。净分数清除率（氟化物剂量的肾清除率/GFR）平均为 56.7%，显着高于对照研究期间观察到的 29%。婴儿的氟化物保留百分比高于成人，可能是因为婴儿在硬组织中沉积氟化物的能力更强。
Fluoride pharmacokinetic data are presented for infants given a fluoride supplement. Seventeen infants participated in a total of 20 studies. On one day, 0.013 mmol (0.25 mg) fluoride was given as a supplement (fluoride supplement study), and on another day a placebo was given (control study). Samples of plasma and urine were collected for 5 h and analyzed for fluoride. During control studies fluoride intake averaged 0.15 mu mol/kg (2.9 mu g/kg), and plasma fluoride concentrations ranged from 0.05 to 0.11 mu mol/L (10 to 20 mu g/L). In nine instances, the quantity of fluoride excreted in the urine was more than twice that consumed. When the fluoride supplement was given, total fluoride intake averaged 1.93 mu mol/kg (36.6 mu g/kg). Plasma peak concentration was reached by 30 min in 14 studies and by 60 min in six studies. Mean plasma peak fluoride concentration was 3.3 mu mol/L (63 ng/mL). Area under the plasma concentration curve averaged 236 nmol.m(-1).min (4479 ng.mL(-1).min) and was not related to the dose of fluoride. The rate of urinary excretion was significantly correlated with rate of urinary flow. When the dose of fluoride was expressed per unit of body weight, fluoride retention was strongly related to the dose. Retention of the fluoride absorbed from the fluoride dose ranged from 75.4 to 87.6%. Plasma clearance averaged 6.8 mL.kg(-1).min(-1) and decreased significantly with age. Net fractional clearance (renal clearance of the fluoride dose/GFR) averaged 56.7%, which was significantly greater than the 29% observed during the control studies. The greater percentage retention of fluoride by infants than by adults is probably explained by a greater capacity of the infant to deposit fluoride in hard tissues.