The first general method for palladium-catalyzed Negishi cross-coupling of aryl and vinyl chlorides:: Use of commercially available Pd(P(t-BU)3)2 as a catalyst
The first general method for palladium-catalyzed Negishi cross-coupling of aryl and vinyl chlorides:: Use of commercially available Pd(P(t-BU)3)2 as a catalyst
复制标题
DOI：
10.1021/ja003954y
复制
发表时间：
2001-03-28
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Dai, CY;Fu, GC
通过单一方案，市售Pd（P（t-Bu）（3））（2）可以实现广泛的芳基和氯乙烯与芳基和烷基锌试剂的Negishi交叉偶联。该方法容许硝基，并且其有效地产生空间位阻联芳基。此外，还可以实现高周转次数（>3000）。
With a single protocol, commercially available Pd(P(t-Bu)(3))(2) can effect the Negishi cross-coupling of a wide range of aryl and vinyl chlorides with aryl- and alkylzinc reagents. The process tolerates nitro groups, and it efficiently generates sterically hindered biaryls. In addition, a high turnover number (>3000) can be achieved.