Developmental pattern of expression of the mouse α1(XI) collagen gene (Col11a1)
Developmental pattern of expression of the mouse α1(XI) collagen gene (Col11a1)
复制标题
小鼠 α1(XI) 胶原蛋白基因 (Col11a1) 表达的发育模式
作者：
H. Yoshioka;K. Iyama;K. Inoguchi;M. Khaleduzzaman;Y. Ninomiya;F. Ramirez
纤维网络密切参与几种形态发生过程，这些过程是脊椎动物胚胎和谐发育的基础。最近的遗传学证据表明，次要的 V 型和 XI 型胶原蛋白分别是非软骨和软骨基质中 I 型和 II 型原纤维形成的关键调节因子。因此，全面了解编码次要胶原类型链的基因的表达和调节与动物形态发生和发育相关。本研究旨在利用原位杂交技术阐明编码小鼠 XI 型胶原 α1 链 (Col11α1) 的基因的胚胎表达模式。 Col11α1 基因的转录本早在妊娠 11 天时就被检测到。 α1(XI) 转录物被发现主要积聚在软骨组织中，例如软骨颅骨和发育中的四肢。与主要软骨特异性胶原蛋白（II 型）一样，Col11α1 也在大脑神经上皮中表达。然而，α1(XI) 转录物在其他几个非软骨位点积累。它们包括成牙本质细胞、骨小梁、心脏房室瓣、舌头、肠道和耳囊。总而言之，数据证实 Col11α1 的表达谱比之前想象的更广泛。这一发现提出了α1(XI)链可能参与具有不同功能特性的阶段和组织特异性三聚体的形成的可能性。 © 1995 wiley-Liss, Inc.
Fibrillar networks are intimately involved in several morphogenetic processes which underlie the harmonious development of the vertebrate embryo. Recent genetic evidence has demonstrated that the minor types V and XI collagen are key regulators of types I and II fibrillogenesis in non‐cartilaginous and cartilaginous matrices, respectively. A comprehensive understanding of the expression and regulation of the genes coding for the chains of the minor collagen types is therefore relevant to animal morphogenesis and development. The present study was undertaken to elucidate the embryonic pattern of expression of the gene coding for the mouse α1 chain of type XI colagen (Col11α1) using the technique of in situ hybridization. Transcripts of the Col11α1 gene were detected as early as 11 days of gestation. The α1(XI) transcripts were found to accumulate mostly in cartilaginous tissues, such as the chondrocranium and the developing limbs. Like the major cartilage‐specific collagen (type II), Col11α1 expression was also noted in the neuro‐epithelium of the brain. However, α1(XI) transcripts accumulated in several other non‐cartilaginous sites. They include odontoblasts, trabecular bones, atrioventricular valve of the heart, the tongue, the intestine, and the otic vesicle. Altogether, the data confirm that Col11α1 has a broader spectrum of expression than previously thought. This finding raises the possibility that the α1(XI) chain may participate in the formation of stage‐ and tissue‐specific trimers with distinct functional properties. © 1995 wiley‐Liss, Inc.
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影响因子：
4
作者：
D. Birk;J. Fitch;J. Babiarz;K. Doane;T. Linsenmayer
通讯作者：
D. Birk;J. Fitch;J. Babiarz;K. Doane;T. Linsenmayer
鸡 α1 (XI) 胶原蛋白基因在胚胎组织中广泛表达。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Nah,HD;Barembaum,M;Upholt,WB
通讯作者：
Upholt,WB
牛血管平滑肌细胞中 α 1(XI) 和 α 2(V) 胶原蛋白 mRNA 的协同调节。
DOI：
--
发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brown,KE;Lawrence,R;Sonenshein,GE
通讯作者：
Sonenshein,GE
DOI：
10.1073/pnas.88.21.9648
发表时间：
1991-11-01
影响因子：
11.1
作者：
GAROFALO, S;VUORIO, E;DECROMBRUGGHE, B
通讯作者：
DECROMBRUGGHE, B
DOI：
10.1016/s0021-9258(18)98361-4
发表时间：
1993-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Richard Mayne;R. G. Brewton;P. M. Mayne;John Baker
通讯作者：
Richard Mayne;R. G. Brewton;P. M. Mayne;John Baker