EVIDENCE FOR ARGININE-VASOPRESSIN AS THE PRIMARY ACTIVATOR OF THE HPA AXIS DURING ADJUVANT-INDUCED ARTHRITIS
EVIDENCE FOR ARGININE-VASOPRESSIN AS THE PRIMARY ACTIVATOR OF THE HPA AXIS DURING ADJUVANT-INDUCED ARTHRITIS
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DOI：
10.1111/j.1476-5381.1995.tb15089.x
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发表时间：
1995-11-01
影响因子：
7.3
通讯作者：
LIGHTMAN, SL
中科院分区：
文献类型：
--
作者：
CHOWDREY, HS;LARSEN, PJ;LIGHTMAN, SL
1 佐剂诱发的关节炎 (AA) 是一种实验性关节炎症，导致下丘脑-垂体-肾上腺 (HPA) 轴慢性激活。2 在这项研究中，下丘脑促肾上腺皮质激素释放因子 (CRF) 和精氨酸加压素 (AVP) 在这种情况下在 Sprague-Dawley (SD) 和 Piebald-Viral-Glaxo 中调节 HPA 轴中的作用(PVG) 大鼠已得到进一步表征。3 关节炎发作前门静脉血 AVP 肽含量增加（早在第 ii 天）得到证实，并进一步增加，在第 16 天达到峰值，与 PVG 大鼠炎症的进展一致。4 AVP 的增加与关节炎下丘脑室旁核 (PVN) 内侧小细胞分裂中 AVP 表达的显着增加相关，但与 CRF mRNA 的表达显着增加无关。 SD 大鼠。5 在 SD 大鼠存在最大炎症的情况下，[I-125]-Tyr-oCRF 与垂体前叶膜的最大结合显着降低，而 PVG 和 SD 大鼠垂体前叶膜中的 AVP 受体浓度相对于对照组显着增加。6 对照和关节炎 SD 大鼠的体外基础促肾上腺皮质激素 (ACTH) 分泌相似，但关节炎 PVG 大鼠的基础促肾上腺皮质激素 (ACTH) 分泌相似垂体显着高于各自的对照（436 +/- 91 v 167 +/- 23 pg/管）。关节炎PVG大鼠垂体对CRF或CRF和AVP组合的ACTH反应显着高于对照组，尽管关节炎SD大鼠垂体的ACTH反应没有变化。 7结果与小细胞加压素系统的激活在HPA轴适应实验诱导的关节炎慢性应激中具有重要作用的观点一致。
1 Adjuvant-induced arthritis (AA) is an experimental inflammation of the joints that results in chronic activation of the hypothalamo-pituitary-adrenal (HPA) axis.2 In this study the role of hypothalamic corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) in the regulation of the HPA axis in this condition both in Sprague-Dawley (SD), and Piebald-Viral-Glaxo (PVG) rats has been further characterized.3 The increase in AVP peptide content of portal blood (as early as day ii), just prior to the onset of arthritis is confirmed and further increases, peaking at day 16 are shown, coincident with the progression of inflammation in the PVG rats.4 The increase in AVP is associated with a significant increase in the expression of AVP but not CRF mRNAs in the medial parvocellular division of the hypothalamic paraventricular nucleus (PVN) of arthritic SD rats.5 In the presence of maximal inflammation of SD rats there was a significant decrease in the maximum binding of [I-125]-Tyr-oCRF to anterior pituitary membranes, whereas AVP receptor concentration in anterior pituitary membranes from both PVG and SD rats showed a significant increase with respect to controls.6 The basal adrenocorticotrophin (ACTH) secretion in vitro was similar in both control and arthritic SD rats but that from arthritic PVG rat pituitaries was significantly greater than the respective controls (436 +/- 91 v 167 +/- 23 pg/tube). The ACTH response of pituitaries of arthritic PVG rats to CRF or the combination of CRF and AVP was significantly higher compared with the controls, although the ACTH response of arthritic SD rat pituitaries was unchanged.7 The results are consistent with the view that activation of the parvocellular vasopressin system has an important role in the adaptation of the HPA axis to experimentally-induced chronic stress of arthritis.