Effects of morphine and opioid peptides on plasma levels of atrial natriuretic peptide.
Effects of morphine and opioid peptides on plasma levels of atrial natriuretic peptide.
复制标题
吗啡和阿片肽对心房钠尿肽血浆水平的影响。
DOI：
10.1016/0024-3205(88)90512-7
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Brown,MR
中科院分区：
文献类型：
--
作者：
Crum,RL;Brown,MR
在清醒、自由活动的 Sprague-Dawley 大鼠中研究阿片配体给药对心房钠尿肽 (ANP) 血浆水平的影响。在脑室内（icv）或中心静脉（iv）注射吗啡（MS）、亮氨酸脑啡肽（Leu-enk）、强啡肽（Dyn）或β-内啡肽（B-endor）之前和之后，获取血浆样本用于通过放射免疫测定法测量ANP浓度。静脉注射时，MS 提高血浆 ANP 水平的效果比静脉注射时强 10 倍。 Icv 注射 Leu-enk 降低血浆 ANP 浓度。 Dyn 和 B-endor 给药（iv 或 icv）不会改变 ANP 的血浆浓度。 MS 和 Leu-enk 对 ANP 血浆浓度的这些影响似乎是通过对中枢神经系统的作用介导的。 静脉注射 MS、Leu-enk、B-endor 和 Dyn 会导致血浆去甲肾上腺素 (NE) 和肾上腺素 (Epi) 浓度升高。当 MS 给予 icv 时，平均 Epi 和 NE 血浆水平增加了 B-endor、Leu-enk 和 Dyn 增加的 10-50 倍。儿茶酚胺在介导 MS 刺激的 ANP 释放中的作用得到了观察结果的支持，即用氯茚明进行神经节阻滞可显着减弱血浆 ANP 水平的增加。MS，但不是 B-endor、Leu-enk 和 Dyn，在大脑内发挥作用，增加血浆 ANP 水平。 MS 引起的血浆 ANP 水平升高可能依赖于完整的自主神经系统。
The effect of opiate ligand administration on plasma levels of atrial natriuretic peptide (ANP) was studued in awake, freely moving Sprague-Dawley rats. Prior to and following the intracerebroventricular (icv) or central venous (iv) injection of morphine (MS), leu-enkephalin (Leu-enk), dynorphin (Dyn) or β-endorphin (B-endor), plasma samples were obtained for measurement of ANP concentrations by radioimmunoassay. MS was 10 times more potent when given icv than when given iv to increase plasma ANP levels. Icv injection of Leu-enk decreased plasma ANP concentrations. Dyn and B-endor administration (iv or icv) did not alter the plasma concentration of ANP. These effects of MS and Leu-enk on plasma concentrations of ANP appear to be mediated through actions on the central nervous system.MS, Leu-enk, B-endor, and Dyn given icv, produced elevations of plasma norepinephrine (NE) and epinephrine (Epi) concentrations. When MS was given icv, mean Epi and NE plasma levels increased 10–50 times the increases noted with B-endor, Leu-enk and Dyn. A role of catecholamines in mediating MS-stimulated ANP release is supported by the observation that ganglionic blockade with chlorisondamine significantly attenuated the increase of plasma ANP levels.MS, but not B-endor, Leu-enk and Dyn, acts within the brain to increase plasma levels of ANP. MS-induced elevations of plasma ANP levels may be dependent on an intact autonomic nervous system.