The activation of the human neutrophil respiratory burst occurs only at temperatures above 17 degrees C: evidence that activation requires membrane fusion.
The activation of the human neutrophil respiratory burst occurs only at temperatures above 17 degrees C: evidence that activation requires membrane fusion.
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人类中性粒细胞呼吸爆发的激活仅在温度高于 17°C 时发生：证据表明激活需要膜融合。
DOI：
10.1016/0006-291x(85)91188-x
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发表时间：
1985
影响因子：
3.1
通讯作者：
Schneider,DL
中科院分区：
文献类型：
--
作者：
Manara,FS;Schneider,DL
通过考虑温度对人体中性粒细胞在肉豆蔻酸佛醇刺激下呼吸爆发活性的影响，我们发现只有在17℃及以上才会发生激活。在20至30°C之间，氧气消耗速率随着细胞中明胶酶和乳铁蛋白的释放而急剧上升。由于它们分别标志着第三颗粒和特定颗粒，在触发呼吸爆发时，一个或两个颗粒与质膜的膜融合是非常可能的。
By considering the effects of temperature on the respiratory burst activity of human neutrophils stimulated by phorbol myristate acetate, we have found that activation only occurs at 17°C and above. Between 20 and 30°C, the rates of oxygen consumption rose dramatically in correspondence with cellular release of gelatinase and lactoferrin. Inasmuch as these mark tertiary and specific granules, respectively, a necessity for membrane fusion of one or both granules with the plasma membrane during triggering of the respiratory burst is very probable.