Regulation of Cancer Metabolic Reprogramming on Immune Microenvironment
Regulation of Cancer Metabolic Reprogramming on Immune Microenvironment
复制标题
癌症代谢重编程对免疫微环境的调节
DOI：
10.16476/j.pibb.2017.0252
复制
发表时间：
2017-08-01
影响因子：
0.3
通讯作者：
Gao Ping
中科院分区：
文献类型：
--
作者：
Sun Lin-Chong;Gao Ping
癌症免疫治疗的成功证明了宿主免疫系统对癌细胞杀伤的关键参与以及抗肿瘤免疫的可行性，而免疫抑制的肿瘤微环境限制了癌症免疫治疗的前进。肿瘤微环境能够诱导肿瘤代谢重编程，该过程导致：（1）肿瘤细胞和宿主免疫细胞之间对营养物质的竞争利用； (2)通过不同的方式调节肿瘤来源的代谢物或废物引起的免疫细胞的激活和效应功能。因此，本文重点综述目前关于肿瘤代谢重编程及相关代谢产物对宿主免疫影响的观点，以期为癌症免疫治疗提供理论依据和新思路。
The success of cancer immunotherapy demonstrates the critical involvement of host immune system on cancer cell killing as well as the feasibility of anti-tumor immunity, whereas the immunosuppressive tumor microenvironment restrains the step forward of cancer immunotherapy. Tumor microenvironment is able to induce tumor metabolic reprogramming and this process leads to: (1) competitive utilization of nutrients between tumor cell and host immune cells; (2) regulation of activation and effector function of immune cells caused by tumor derived metabolites or waste through different modes. Thus, this review focuses on current views of the influence of tumor metabolic reprogramming and relevant metabolites on host immune, in order to provide theoretical basis and new ideas for cancer immunotherapy.