Polycystic ovary syndrome and risk for long-term diabetes and dyslipidemia.
Polycystic ovary syndrome and risk for long-term diabetes and dyslipidemia.
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DOI：
10.1097/aog.0b013e31820209bb
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发表时间：
2011-01
影响因子：
7.2
通讯作者：
Bibbins-Domingo K
中科院分区：
文献类型：
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作者：
Wang ET;Calderon-Margalit R;Cedars MI;Daviglus ML;Merkin SS;Schreiner PJ;Sternfeld B;Wellons M;Schwartz SM;Lewis CE;Williams OD;Siscovick DS;Bibbins-Domingo K
评估符合美国国立卫生研究院（NIH）多囊卵巢综合征（PCOS）标准的19-32岁女性随后发生糖尿病、血脂异常和高血压的风险是否较高，并评估体重正常的多囊卵巢综合征女性是否与超重的多囊卵巢综合征女性具有相同程度的心血管风险。我们在青年人冠状动脉风险发展（CARDIA）队列中对1127名白人女性和黑人女性进行了为期18年的研究，评估了多囊卵巢综合征与糖尿病、血脂异常和高血压的关系。我们根据美国国立卫生研究院多囊卵巢综合征标准，根据自我报告的症状和/或生化高雄激素症，在基线（20-32岁）对女性进行分类。我们使用多变量logistic回归估计PCOS与随后的心血管危险因素的关联，独立于基线体重指数（BMI）。此外，在746名34-46岁进行PCOS第二次评估的女性中，我们估计了持续性PCOS与心血管危险因素的关联。在1127名女性中，53名（4.7%）在20-32岁时符合PCOS标准。PCOS与18年内发生糖尿病（23.1% vs 13.1%；调整OR (AOR) 2.4, 1.2-4.9）和血脂异常（41.9% vs 27.7%; AOR 1.9, 1.0-3.6）的几率高两倍相关；与高血压事件的相关性不显著（26.9%对26.3%；AOR为1.7,0.8-3.3）。体重正常的多囊卵巢综合征女性（n=31）发生糖尿病的几率是体重正常的无多囊卵巢综合征女性的三倍（AOR 3.1, 1.2-8.0）。与没有多囊卵巢综合征的女性（n=11）相比，持续性多囊卵巢综合征的女性患糖尿病的几率最高（AOR为7.2,1.1-46.5）。多囊卵巢综合征与随后发生的糖尿病和血脂异常有关，与BMI无关。患有持续性多囊卵巢综合征的女性患糖尿病的风险最大。
To estimate whether women aged 19–32 who fulfilled National Institutes of Health (NIH) criteria for polycystic ovary syndrome (PCOS) would be at a higher risk for subsequent development of incident diabetes, dyslipidemia, and hypertension, and to estimate whether normal-weight women with PCOS would have the same degree of cardiovascular risk as overweight women with PCOS. We estimated the association of PCOS with incident diabetes, dyslipidemia, and hypertension over a period of 18 years among 1,127 white women and black women in the Coronary Artery Risk Development In young Adults (CARDIA) cohort. We classified women at baseline (ages 20–32) based on self-reported symptoms and/or biochemical hyperandrogenism using NIH PCOS criteria. We estimated the association of PCOS and subsequent cardiovascular risk factors, independent of baseline body mass index (BMI), using multivariable logistic regression. Additionally, among 746 women with a second assessment of PCOS at ages 34–46, we estimated the association of persistent PCOS with cardiovascular risk factors. Of 1,127 women, 53 (4.7%) met criteria for PCOS at ages 20–32. PCOS was associated with a twofold higher odds of incident diabetes (23.1% versus 13.1%; adjusted OR (AOR) 2.4, 1.2–4.9) and dyslipidemia (41.9% versus 27.7%; AOR 1.9, 1.0–3.6) over 18 years; the association with incident hypertension was not significant (26.9% versus 26.3%; AOR 1.7, 0.8–3.3). Normal-weight women with PCOS (n=31) had a threefold higher odds of incident diabetes compared to normal weight women without PCOS (AOR 3.1, 1.2–8.0). Compared to those without PCOS (n=11), women with persistent PCOS had the highest odds of diabetes (AOR 7.2, 1.1–46.5). PCOS is associated with subsequent incident diabetes and dyslipidemia, independent of BMI. Diabetes risk may be greatest for women with persistent PCOS symptoms.