Molecular and genomic aberrations in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas.
Molecular and genomic aberrations in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas.
复制标题
鹦鹉热衣原体阴性眼附件边缘区淋巴瘤的分子和基因组畸变。
DOI：
10.1002/ajh.23490
复制
发表时间：
2013
影响因子：
12.8
通讯作者：
Lossos,IzidoreS
中科院分区：
文献类型：
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作者：
Zhu,Daxing;Ikpatt,OffiongF;Dubovy,SanderR;Lossos,Chen;Natkunam,Yasodha;Chapman-Fredricks,JenniferR;Fan,Yao-Shan;Lossos,IzidoreS
The etiology and pathogenesis of ocular adnexal extranodal marginal zone lymphoma (OAEMZL) are still unknown and the association withChlamydophila psittaci (C. psittaci) has been shown in only some geographic regions. Herein, we comprehensively examined the frequency of chromosomal translocations as well as CARD11, MYD88 (L265P), and A20 mutations/deletions in 45C. psittacinegative OAEMZLs. t(14;18)(q32;q21) IGH‐MALT1 and t(11;18)(q21;q21) API2‐MALT1 were not detected in any of the analyzed tumors while three tumors harboredIGHtranslocations to an unidentified partner. CARD11 mutations were not found in all analyzed tumors, while the MYD88 L265P mutation was detected in three (6.7%) tumors. A20 mutations and deletions were each detected in seven (15.6%) and six (13.3%) tumors, respectively. Therefore, the observed genetic aberrations could account for the activation of the nuclear factor (NF)‐kB signaling pathway in only a minority of the cases. Further studies are needed to identify the molecular mechanisms underlying the pathogenesis of OAEMZL. Am. J. Hematol. 88:730–735, 2013. © 2013 Wiley Periodicals, Inc.
