ALTERED MONAMINE METABOLISM IN CAUDATE-PUTAMEN OF IRON-DEFICIENT RATS
ALTERED MONAMINE METABOLISM IN CAUDATE-PUTAMEN OF IRON-DEFICIENT RATS
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DOI：
10.1016/0091-3057(94)90323-9
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发表时间：
1994-07-01
影响因子：
3.6
通讯作者：
JONES, BC
中科院分区：
文献类型：
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作者：
BEARD, JL;CHEN, Q;JONES, BC
利用体内微透析技术研究缺铁对脑单胺代谢的影响尚未见报道。因此，我们用体内微透析法检测了11周龄缺铁性贫血大鼠和对照组(Hb&Gt；14g/dl)大鼠脑尾壳核中的单胺类、多巴胺和去甲肾上腺素及其代谢产物。在4小时内采集的样本中，铁缺乏大鼠的尾壳胺、二羟基苯乙酸和高香草酸的浓度分别增加了53%、57%和30%(p<；0.001)。虽然之前已经报道过D受体数量减少，但目前的发现表明，单胺摄取和分解代谢存在额外的缺陷。
The effect of iron deficiency on brain monoamine metabolism using in vivo microdialysis techniques has not been previously reported. We, therefore, examined the monoamines, dopamine and norepinephrine, and their metabolites at steady state by in vivo microdialysis in rat brain caudate-putamen in 11-week-old iron-deficient anemic hemoglobin < 7 g/dl) and control rats (Hb > 14 g/dl). Caudateputamen dopamine DA), dihydroxyphenyl acetic acid DOPAC), and homovanillic acid (HVA) concentrations were increased by 53%, 57%, and 30% (p < 0.001), respectively, in iron-deficient rats in samples collected over a 4-h period. While diminished numbers of D, receptors have been previously reported, the present findings suggest an additional defect in monoamine uptake and catabolism.