Macrophage diversity enhances tumor progression and metastasis.
Macrophage diversity enhances tumor progression and metastasis.
复制标题
DOI：
10.1016/j.cell.2010.03.014
复制
发表时间：
2010-04-02
期刊：
影响因子：
64.5
通讯作者：
Pollard JW
中科院分区：
文献类型：
--
作者：
Qian BZ;Pollard JW
有令人信服的临床和实验证据表明，巨噬细胞促进癌症的发生和恶性进展。在肿瘤发生过程中，它们创造了一个致突变的炎症环境，促进了肿瘤的生长。随着肿瘤向恶性发展，巨噬细胞刺激血管生成，增强肿瘤细胞的迁移、侵袭，抑制抗肿瘤免疫。在转移部位，巨噬细胞为肿瘤细胞的到达准备靶组织，然后不同的巨噬细胞亚群促进肿瘤细胞外渗、存活和随后的生长。特殊的巨噬细胞亚群可能是重要的新治疗靶点。
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation they create an inflammatory environment that is mutagenic and which promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration, invasion, and suppress anti-tumor immunity. At metastatic sites macrophages prepare the target tissue for arrival of tumor cells and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.