Well-Defined Oligo- and Polysaccharides as Ideal Probes for Structural Studies
Well-Defined Oligo- and Polysaccharides as Ideal Probes for Structural Studies
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DOI：
10.1021/jacs.8b00254
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发表时间：
2018-04-25
影响因子：
15
通讯作者：
Seeberger, Peter H.
中科院分区：
文献类型：
--
作者：
Delbianco, Martina;Kononov, Andrew;Seeberger, Peter H.
多糖是自然界中最丰富的有机物质，但它们的三维结构和宏观性质之间的相关性尚未建立。自动化聚糖组装使得能够制备类似于天然和非天然结构的明确定义的寡糖和多糖。这些人工合成的聚糖是多糖基础研究的理想探针。根据分子模型模拟和NMR分析，不同类别的多糖采用根本不同的构象，这些构象通过单位点取代而急剧改变。较大的合成多糖是通过类似“乐高”的方法获得的，作为生产定制的碳水化合物基材料的第一步。
Polysaccharides are the most abundant organic materials in nature, yet correlations between their three-dimensional structure and macroscopic properties have not been established. Automated glycan assembly enables the preparation of well-defined oligo- and polysaccharides resembling natural as well as unnatural structures. These synthetic glycans are ideal probes for the fundamental study of polysaccharides. According to molecular modeling simulations and NMR analysis, different classes of polysaccharides adopt fundamentally different conformations that are drastically altered by single-site substitutions. Larger synthetic polysaccharides are obtained via a "LEGO"-like approach as a first step toward the production of tailor-made carbohydrate-based materials.