Cyclic adenosine 3',5'-monophosphate concentration in plasma, adipose tissue and skeletal muscle in normal subjects and in patients with hyper- and hypothyroidism.
Cyclic adenosine 3',5'-monophosphate concentration in plasma, adipose tissue and skeletal muscle in normal subjects and in patients with hyper- and hypothyroidism.
复制标题
正常受试者以及甲状腺功能亢进症和甲状腺功能减退症患者血浆、脂肪组织和骨骼肌中环腺苷 3,5-单磷酸浓度。
DOI：
10.1210/jcem-39-1-96
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
R. Andersson
中科院分区：
文献类型：
--
作者：
B. Karlberg;K. Henriksson;R. Andersson
ABSTRACT Plasma and tissue concentrations of cyclic AMP were studied in 11 hyperthyroid patients (mean PBI 14.6 μg/100 ml) and 10 patients with primary hypothyroidism (mean PBI 1.6 μg/100ml). These results were compared with the values obtained in 13 euthyroid control subjects (mean PBI 5.6 μg/100 ml). Mean ± SEM plasma concentrations for the groups were: hyperthyroidism 23.6 ± 2.2 nm, primary hypothyroidism 5.1 ± 0.7 nm. Both these levels differed significantly (p < 0.001) from that of euthyroid control subjects (10.7 ± 0.6 nm). Treatment with propranolol 160 mg/day orally in 5 hyperthyroid patients resulted in reduction of plasma cyclic AMP levels to that of euthyroid subjects. Plasma concentrations of cyclic AMP were found to be about 1% of the tissue levels. Cyclic AMP levels in skeletal muscle averaged 1.5 ± 0.3 nmole/g wet weight in hyperthyroid patients and in adipose tissue 1.5 ± 0.3 nmole/g. Both these levels were significantly higher than in euthyroid subjects (p < 0.02). In hypothyroid patients...
