Development of a PET/Cerenkov-light hybrid imaging system.
Development of a PET/Cerenkov-light hybrid imaging system.
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DOI：
10.1118/1.4893535
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发表时间：
2014-09
期刊：
影响因子：
3.8
通讯作者：
S. Yamamoto;Fuka Hamamura;T. Watabe;Hayato Ikeda;Y. Kanai;H. Watabe;Katsuhiko Kato;Y. Ogata;J. Hatazawa
中科院分区：
文献类型：
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作者：
S. Yamamoto;Fuka Hamamura;T. Watabe;Hayato Ikeda;Y. Kanai;H. Watabe;Katsuhiko Kato;Y. Ogata;J. Hatazawa
切伦科夫光成像是一种新型分子成像技术，利用高灵敏度光学相机检测高速电子中的可见光子。然而，切伦科夫光成像的优点仍然不清楚。如果开发出PET/Cerenkov-light混合成像系统，那么通过直接比较这两种成像方式，就可以明确Cerenkov-light成像的优点。方法研制并测试了一种PET/Cerenkov-light混合成像系统，该系统由一个双头PET系统、一个位于受试者上方的反射镜和一个高灵敏度电荷耦合器件（CCD）相机组成。作者将这些系统安装在一个黑盒中，用于对切伦科夫光进行成像。双头PET系统采用了一个1.2×1.2×10 mm3的GSO排列在33 × 33的矩阵中，与位置敏感光电倍增管光学耦合形成GSO块探测器。作者安排了两个GSO块探测器相距10厘米，并将受试者置于它们之间。被摄体上方的切伦科夫光被反射镜反射并改变其方向到PET系统的一侧，由高灵敏度CCD相机成像。结果双头PET系统在视场中心的空间分辨率为~ 1.2 mm FWHM，灵敏度为~ 0.31%。对于22Na点源，切伦科夫光成像系统的空间分辨率为~ 275 μm。利用PET/Cerenkov-light混合成像系统，成功地从同时采集的图像中获得融合图像。在切伦科夫光图像中，由于被摄物体内的光传输和吸收，图像分布有时会有所不同。在对大鼠的同时成像中，作者发现PET图像上18F-FDG主要集中在哈德氏腺，而切伦科夫光分布在眼睛中。结论所研制的PET/Cerenkov-light混合成像系统有助于评价Cerenkov-light成像在分子成像研究中的优点和局限性。
PURPOSE Cerenkov-light imaging is a new molecular imaging technology that detects visible photons from high-speed electrons using a high sensitivity optical camera. However, the merit of Cerenkov-light imaging remains unclear. If a PET/Cerenkov-light hybrid imaging system were developed, the merit of Cerenkov-light imaging would be clarified by directly comparing these two imaging modalities. METHODS The authors developed and tested a PET/Cerenkov-light hybrid imaging system that consists of a dual-head PET system, a reflection mirror located above the subject, and a high sensitivity charge coupled device (CCD) camera. The authors installed these systems inside a black box for imaging the Cerenkov-light. The dual-head PET system employed a 1.2×1.2×10 mm3 GSO arranged in a 33 × 33 matrix that was optically coupled to a position sensitive photomultiplier tube to form a GSO block detector. The authors arranged two GSO block detectors 10 cm apart and positioned the subject between them. The Cerenkov-light above the subject is reflected by the mirror and changes its direction to the side of the PET system and is imaged by the high sensitivity CCD camera. RESULTS The dual-head PET system had a spatial resolution of ∼1.2 mm FWHM and sensitivity of ∼0.31% at the center of the FOV. The Cerenkov-light imaging system's spatial resolution was ∼275 μm for a 22Na point source. Using the combined PET/Cerenkov-light hybrid imaging system, the authors successfully obtained fused images from simultaneously acquired images. The image distributions are sometimes different due to the light transmission and absorption in the body of the subject in the Cerenkov-light images. In simultaneous imaging of rat, the authors found that 18F-FDG accumulation was observed mainly in the Harderian gland on the PET image, while the distribution of Cerenkov-light was observed in the eyes. CONCLUSIONS The authors conclude that their developed PET/Cerenkov-light hybrid imaging system is useful to evaluate the merits and the limitations of Cerenkov-light imaging in molecular imaging research.