Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults
Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults
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DOI：
10.1016/j.yhbeh.2015.05.024
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发表时间：
2015-08-01
影响因子：
3.5
通讯作者：
Galea, Liisa A. M.
中科院分区：
文献类型：
--
作者：
Duarte-Guterman, Paula;Yagi, Shunya;Galea, Liisa A. M.
这篇文章是特刊“雌二醇与认知”的一部分。海马体依赖性认知和神经发生存在性别差异，表明性激素参与其中。雌激素调节成年雌性啮齿动物海马中某些形式的空间和环境记忆和神经发生，雄性海马的作用较小。本文综述了性别和雌激素对年轻和老年成年啮齿动物海马学习、记忆和神经发生的影响。我们讨论了诸如雌激素类型、治疗持续时间和剂量、治疗时间和记忆类型等因素如何影响雌激素对认知和神经发生的作用。我们还讨论了生殖经验（怀孕和育儿）和衰老如何与雌激素相互作用，以调节雌性海马认知和神经发生。鉴于有证据表明成人海马神经发生在长期空间记忆和模式分离中起作用，我们还讨论了调节海马神经发生的功能意义。(C) 2015爱思唯尔公司版权所有。
This article is part of a Special Issue "Estradiol and Cognition".There are sex differences in hippocampus-dependent cognition and neurogenesis suggesting that sex hormones are involved. Estrogens modulate certain forms of spatial and contextual memory and neurogenesis in the adult female rodent, and to a lesser extent male, hippocampus. This review focuses on the effects of sex and estrogens on hippocampal learning, memory, and neurogenesis in the young and aged adult rodent. We discuss how factors such as the type of estrogen, duration and dose of treatment, timing of treatment, and type of memory influence the effects of estrogens on cognition and neurogenesis. We also address how reproductive experience (pregnancy and mothering) and aging interact with estrogens to modulate hippocampal cognition and neurogenesis in females. Given the evidence that adult hippocampal neurogenesis plays a role in long-term spatial memory and pattern separation, we also discuss the functional implications of regulating neurogenesis in the hippocampus. (C) 2015 Elsevier Inc. All rights reserved.