Aerosolized surfactant and dextran for experimental acute respiratory distress syndrome caused by acidified milk in rats
Aerosolized surfactant and dextran for experimental acute respiratory distress syndrome caused by acidified milk in rats
复制标题
DOI：
10.1034/j.1399-6576.2003.00168.x
复制
发表时间：
2003-08-01
影响因子：
2.1
通讯作者：
Kobayashi, T
中科院分区：
文献类型：
--
作者：
Cui, XG;Tashiro, K;Kobayashi, T
背景：血浆来源蛋白对肺表面活性物质的抑制是急性呼吸窘迫综合征（ARDS）的重要发病因素。吸入雾化表面活性剂可能适合ARDS的早期治疗。然而，需要高剂量是一个缺点。由于右旋糖酐可逆转表面活性剂的抑制作用，因此我们通过右旋糖酐是否能提高雾化表面活性剂对实验性ARDS大鼠的治疗效果。方法：将酸化牛奶（pH 1.8，1.5 ml kg(-1)）注入纯氧通气大鼠气管内，吸气峰值压2.45 kPa，正压0.74 kPa。 呼气末压力。当 PaO2 降至
Background: Inhibition of pulmonary surfactant by plasma-derived proteins is an important pathogenetic factor of acute respiratory distress syndrome (ARDS). Inhalation of aerosolized surfactant may be suitable for early treatment of ARDS. However, requirement of a high dose is a drawback. Because dextran reverses surfactant inhibition, we examined whether dextran improves the therapeutic effects of aerosolized surfactant in rats with experimental ARDS.Methods: Acidified milk (pH 1.8, 1.5 ml kg(-1)) was injected into the trachea of the rats ventilated with pure oxygen using 2.45 kPa peak inspiratory pressure and 0.74 kPa positive end-expiratory pressure. When PaO2 decreased to