Insulin-stimulated release Of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome
Insulin-stimulated release Of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome
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DOI：
10.1016/j.metabol.2008.05.008
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发表时间：
2008-10-01
影响因子：
9.8
通讯作者：
Nestler, John E.
中科院分区：
文献类型：
--
作者：
Cheang, Kai I.;Baillargeon, Jean-Patrice;Nestler, John E.
胰岛素的某些作用是由肌醇磷酸聚糖（IPG）介导的。多囊卵巢综合征（PCOS）女性患者中，一种假定的含有D-手性肌醇（DCI）的IPG介质的释放不足可能会导致胰岛素抵抗。以前，我们证明口服DCs补充剂改善了PCOS妇女的排卵和代谢参数。然而，口服DCI是否介导了DCI-IPG介导剂释放的增加以及PCOS女性胰岛素敏感性的改善尚不清楚。我们进行了一项随机对照试验，在间隔6周的2个时间点对II型PCOS妇女进行了DCI补充剂与安慰剂的比较。在基线和研究结束时评估口服葡萄糖耐量试验期间的血浆DCI、DCI-IPG释放（AUC（DCI-IPG））和通过频繁采样的静脉内葡萄糖耐量试验的胰岛素敏感性（S-i）。由于研究药物突然不可用，研究提前终止。然而.在不考虑治疗分配的所有受试者中，6周期间存在正相关性（r = 0.69 P = 0.02）。在校正体重指数后（P = 0.22）和进一步校正体重指数和治疗分配后（P = 0.0261），AUC（DCI-1 PG）/AUC（胰岛素）比值的变化与S-i的变化之间保持显著性。这表明，在PCOS女性中，葡萄糖刺激的DCI-IPG释放增加与PCOS治疗干预的胰岛素改善显著相关。(C)2008年爱思唯尔公司All rights reserved.
Some actions Of insulin are mediated by inositolphosphoglycan (IPG) mediators. Deficient release of a Putative D-chiro-inositol-containing (DCI) IPG mediator may contribute to insulin resistance in women with polycystic ovary syndrome (PCOS). Previously, we demonstrated that oral DC] Supplementation improved ovulation and metabolic parameters in women with PCOS. However, whether oral DCI mediates in increase in the release of the DCI-IPG mediator and an improvement in insulin sensitivity in women with PCOS is unknown. We conducted a randomized controlled trial of DCI supplementation vs placebo in I I women with PCOS who were assessed at 2 time points 6 weeks apart. Plasma DCI, DCI-IPG release during oral glucose tolerance test (AUC(DCI-IPG)), and insulin sensitivity (S-i) by frequently sampled intravenous glucose tolerance test were assessed at baseline and end of study. The study was terminated early because of a sudden Unavailability of the study drug. However. ill all Subjects without regard to treatment assignment, there was a positive correlation the 6-week period (r = 0.69 P =.02). which remained between the change in AUC(DCI-1PG)/AUC(insulin) ratio and the change in S-i during the 6 significant after adjustment for body mass index (P = 0.22) and after further adjustment for body mass index and treartment allocation (P = .0261). This suggests that, in women with PCOS, increased glucose-stimulated DCI-IPG release is significantly correlated with improved insulin for therapeutic interventions in PCOS. (C) 2008 Elsevier Inc. All rights reserved.