EFFECTS OF 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN (8-OH-DPAT) ON LOCOMOTOR-ACTIVITY AND REARING OF MICE AND RATS
EFFECTS OF 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN (8-OH-DPAT) ON LOCOMOTOR-ACTIVITY AND REARING OF MICE AND RATS
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DOI：
10.1007/bf02247129
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发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
ANGEBYMOLLER, K
中科院分区：
文献类型：
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作者：
EVENDEN, JL;ANGEBYMOLLER, K
8-OH-DPAT对运动活动的影响还没有明确的定义。Tricklebank等人。(1984)和Dourish等人。(1986)提供的证据表明(1984)和Fourish等人。(1985)提供了8-OH-DPAT增加活性的证据，而Mittman和Geyer(1989)，HilLegaart等人。()和Carli等人。(1989)建议它被药物减少。本研究观察了8-羟基-DPAT对习惯性冰和非习惯性冰大鼠的活动能力和饲养能力的影响。在小鼠和大鼠中，药物的作用分别被跟踪了2小时和4小时。在未习服的小鼠和大鼠中，0.1 mg/kg或更多的8-OH-DPAT剂量在注射后活动控制水平最高的时期阻断活动。然而，在小鼠约60分钟和大鼠约150分钟后，观察到明显的活动增加，随后是一段增加饲养的时期。在习惯化的小鼠中，也观察到了这种对响尾蛇活动的双相影响，但饲养没有增加。习惯性大鼠的运动活动没有减少，而是双相增加。8-OH-DPAT对注射后即刻运动活动的影响被解释为是形成5-羟色胺综合征一部分的刻板的、不协调的“行走”的结果，并导致活动水平介于非习惯性大鼠和习惯性大鼠之间。8-OH-DPAT在注射60分钟或更长时间后产生更高的运动活性和增加站立能力的机制尚不清楚，但可能是由于脑部药物浓度降至较低但仍有效的水平所致。
The effects of 8-OH-DPAT on locomotor activity have not yet been clearly defined. Tricklebank et al. (1984) and Dourish et al. (1986) provide evidence that (1984) and Fourish et al. (1985) provide evidence that 8-OH-DPAT increases activity, whereas Mittman and Geyer (1989), Hillegaart et al. (1989) and Carli et al. (1989) suggest that it is reduced by the drug. In the present study, the effects of 8-OH-DPAT on locomotor activity and rearing were examined in habituated and unhabituated ice and rats. The effects of the drug were followed for up to 2 h in the mouse and up to 4 h in the rat. In unhabituated mice and rats, doses of 0.1 mg/kg or more of 8-OH-DPAT blocked activity during the period post-injection when control levels of activity were highest. However, after about 60 min in mice and 150 min in the rat marked hyperactivity was observed, which was followed by a period of increased rearing. In habituated mice this biphasic effect on locomptor activity was also observed, but there was no increase in rearing. In habituated rats there was no decrease in locomotor activity, rather a biphasic, increase was observed. The effects of 8-OH-DPAT on locomotor activity immediately post-injection are interpreted as being a result of the stereotyped, uncoordinated "ambulation" which forms a part of the 5-HT syndrome, and which results in a level of activity intermediate between that of unhabituated and habituated rats. The mechanism by which 8-OH-DPAT produces elevated locomotor activity and increased rearing seen 60 min or more post-injection is not yet known, but may be a result of brain concentrations of the drug falling to a low, but still effective level.