Bioabsorbable zinc alloys for use in urological surgery
Bioabsorbable zinc alloys for use in urological surgery
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DOI：
10.1007/s00345-023-04342-x
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发表时间：
2023-03
影响因子：
3.4
通讯作者：
Sano Takanori;N. Hinata;Ryoya Kobayashi;Tatsuya Nakatsuji;Y. Okamura;J. Furukawa;Y. Nakano;T. Mukai;M. Fujisawa
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文献类型：
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作者：
Sano Takanori;N. Hinata;Ryoya Kobayashi;Tatsuya Nakatsuji;Y. Okamura;J. Furukawa;Y. Nakano;T. Mukai;M. Fujisawa
目的非吸收性金属夹广泛应用于泌尿外科手术，术中可能与开放性尿路接触。因此，有报告称尿路中出现了杂散夹子和相关的顽固性感染。我们开发了一种生物可吸收的金属，并评估它是否会溶解，如果它误入urinary tract.MethodsWe制备了四种类型的合金，主要包括锌（Zn）与少量的镁（Mg）和锶（Sr），和生物效应，降解性，强度和延展性进行了研究。将每种合金植入5只大鼠的膀胱中4、8和12周。取出合金并评价降解性、结石粘附和组织变化。Zn-Mg-Sr合金在大鼠实验中具有良好的可降解性，无结石粘连，并植入5只猪膀胱内24周。结果Zn-Mg-Sr合金在12周时的降解率最高，为6.51%。在猪实验中，24周时的降解率为3.72%。没有猪的血液中的锌或镁浓度的变化。总体而言，膀胱切口愈合，大体病理学显示伤口愈合。此外，这些合金易于加工，可以形成各种形状，例如斯台普斯，使其在机器人手术中非常有用。
PurposeNon-absorbable clips are widely used in urologic surgery and they may come in contact with an open urinary tract intraoperatively. As a result, stray clips in the urinary tract and associated intractable infections have been reported. We developed a bioabsorbable metal and evaluated whether it would dissolve if it strayed into the urinary tract.MethodsWe prepared four types of alloys mainly comprising zinc (Zn) with small amounts of magnesium (Mg) and strontium (Sr), and the biological effects, degradability, strength, and ductility were investigated. Each alloy was implanted in the bladder of five rats for 4, 8, and 12 weeks. The alloys were removed and evaluated for degradability, stone adhesion, and tissue changes. The Zn–Mg–Sr alloy had degradability and no stone adhesion in the rat experiments, and it was implanted in the bladders of five pigs for 24 weeks. The Mg and Zn levels in the blood were measured, and staple changes were confirmed by cystoscopy.ResultsZn–Mg–Sr alloys showed the best degradability of 6.51% at 12 weeks. In pig experiments, the degradation rate was 3.72% at 24 weeks. None of the pigs had changes in the Zn or Mg concentrations in the blood. Overall, the bladder incision was healed and the gross pathology showed wound healing.ConclusionsThe Zn–Mg–Sr alloys were safely used in animal experiments. Furthermore, the alloys are easy to process and can be formed into various shapes, such as staples, making them useful in robotic surgery.