The Direct and Indirect Costs of Opioid-Induced Constipation
The Direct and Indirect Costs of Opioid-Induced Constipation
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DOI：
10.1016/j.jpainsymman.2010.02.019
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发表时间：
2010-11-01
影响因子：
4.7
通讯作者：
Hjortsberg, Catharina
中科院分区：
文献类型：
--
作者：
Hjalte, Frida;Berggren, Anna-Carin;Hjortsberg, Catharina
使用强阿片类药物治疗与频繁且成问题的副作用有关，其中最常见的副作用之一是阿片类药物引起的便秘（OIC）。OIC的不适可能限制疼痛治疗的有效性。因为便秘通常会在阿片类药物治疗期间持续存在，因此需要认真对待其对患者生活质量（QoL）的影响。本研究基于瑞典一项非介入性研究UPPSIKT的患者数据，成本分析基于197名接受强阿片类药物治疗6个月的患者，本文中的直接和间接成本计算为每个患者每月。结果重度便秘患者每个患者月的总成本显著高于轻度、中度或无便秘患者。重度便秘患者的总成本最高，为1525欧元/患者月，而轻度、中度和无便秘患者的总成本分别为1196欧元、1088欧元和1034欧元。结论阿片类药物的使用对社会是昂贵的，并且成本随OIC的严重程度而变化OIC令人不适，影响患者的生活质量，并可能限制有效的疼痛治疗[J]疼痛症状管理，2010,40 696-703 (C) 2010美国癌症疼痛缓解委员会出版Elsevier Inc .版权所有
Context Treatment with strong opioids is connected with frequent and problematic side effects One of the most common side effects is opioid-induced constipation (OIC) The discomfort of OIC can limit the effectiveness of pain therapy Because constipation typically persists for as long as opioid therapy is administered, its effects on the quality of life (QoL) of patients need to be taken seriously Data and published studies on the cost implications of OIC are, however, scarceObjectives To estimate the direct and indirect costs of OIC in a defined patient population during treatment with strong opioidsMethods The study is based on patient data from a Swedish noninterventional study, UPPSIKT The cost analysis is based on 197 patients treated with strong opioids over a six-month period Direct and indirect costs in this article are calculated per patient-month, and the cost for OIC is estimated as the difference in mean costs between months with and without constipationResults The total costs per patient-month for patients with severe constipation are significantly higher than those for patients with mild, moderate, or no constipation Patients with severe constipation have the highest total costs, Euro (EUR) 1525 per patient-month, whereas patients with mild, moderate, and no problems cost EUR 1196, EUR 1088, and EUR 1034, respectivelyConclusion Opioid use is costly to society, and the costs vary with OIC severity OIC is discomforting, affects the QoL of patients, and can limit an effective pain therapy J Pain Symptom Manage 2010,40 696-703 (C) 2010 US Cancer Pain Relief Committee Published by Elsevier Inc All rights reserved