Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients.
Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients.
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中国甲状腺肿瘤患者 CAPZB 内含子 rs12045440 多态性与血清 TSH 浓度之间的关联。
DOI：
10.1155/2015/250542
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发表时间：
2015
影响因子：
2.8
通讯作者：
Lv Z
中科院分区：
文献类型：
--
作者：
Feng S;Lin S;Zou J;Wang Y;Ji Q;Lv Z
本研究旨在探讨CAPZB基因先导单核苷酸多态性rs10917468和rs12045440不同基因型对甲状腺乳头状癌（PTC）和甲状腺良性肿瘤（BN）患者甲状腺功能的影响。在本研究中，检测到rs12045440与甲状腺肿瘤患者血清TSH浓度显著相关（p = 0.001）。校正相关协变量后，不同rs12045440基因型血清TSH水平在BN组中差异仍显著（p = 0.003），而在PTC组中差异不显著（p = 0.115）。rs10917468与TSH水平无显著相关性。SNP rs12045440与中国甲状腺肿瘤患者，尤其是良性甲状腺肿瘤患者血清TSH浓度相关。
The aim of this study was to investigate the possible influence of different genotypes of the lead single nucleotide polymorphisms (SNPs) rs10917468 and rs12045440 in the CAPZB gene on the thyroid function in papillary thyroid carcinoma (PTC) and benign thyroid neoplasm (BN) patients. In the study, a significant association was detected between rs12045440 and serum TSH concentrations in thyroid tumor patients (p = 0.001). After the adjustment of relevant covariates, the difference between the mean serum TSH levels in different genotypes of rs12045440 was still significant in the BN group (p = 0.003) but was not significant in the PTC cases (p = 0.115). No significant association of rs10917468 with TSH levels was found. The SNP rs12045440 was associated with the serum TSH concentrations in Chinese thyroid tumor patients, especially in benign thyroid tumor cases.