Differential Modulation of Human Intestinal Bifidobacterium Populations after Consumption of a Wild Blueberry (Vaccinium angustifolium) Drink
Differential Modulation of Human Intestinal Bifidobacterium Populations after Consumption of a Wild Blueberry (Vaccinium angustifolium) Drink
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DOI：
10.1021/jf402495k
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发表时间：
2013-08-28
影响因子：
6.1
通讯作者：
Porrini, Marisa
中科院分区：
文献类型：
--
作者：
Guglielmetti, Simone;Fracassetti, Daniela;Porrini, Marisa
双歧杆菌作为促进健康的细菌越来越受到关注。尽管如此，该属包括几个物种，它们对人类宿主的影响不同。先前的研究表明，野生蓝莓饮料的消费可以选择性地增加肠道双歧杆菌，这表明野生蓝莓中的多酚和纤维具有重要作用。本研究评价了在相同粪便样品中栖息于人类肠道中的最常见和最丰富的双歧杆菌分类群的调节。分析表明，B.你好，B。breve，B. catenulatum/pseudocatelulatum和B.长双歧杆菌婴儿亚种在入组的受试者中，Longum始终存在，而B.两歧和B.长双歧杆菌婴儿亚种但他们没有。此外，发现最主要的双歧杆菌物种是B。长双歧杆菌婴儿亚种longum和B.好吧所得结果显示个体间变异性较高;然而，B显著增加。长双歧杆菌婴儿亚种在野生蓝莓饮料治疗后，观察志愿者粪便中的黑色素细胞浓度。该双歧杆菌群被证明具有免疫调节能力，并缓解症状和促进几种胃肠道疾病的消退。因此，增加了B.长双歧杆菌婴儿亚种人类肠道中的细菌可以被认为具有潜在的健康益处。总之，野生蓝莓的消费导致了特定的生物合成效应，可以积极影响某些生物合成细菌的种群，具有促进健康的特性。
Bifidobacteria are gaining increasing interest as health-promoting bacteria. Nonetheless, the genus comprises several species, which can exert different effects on human host. Previous studies showed that wild blueberry drink consumption could selectively increase intestinal bifidobacteria, suggesting an important role for the polyphenols and fiber present in wild blueberries. This study evaluated the modulation of the most common and abundant bifidobacterial taxonomic groups inhabiting the human gut in the same fecal samples. The analyses carried out showed that B. adolescentis, B. breve, B. catenulatum/pseudocatelulatum, and B. longum subsp. longum were always present in the group of subjects enrolled, whereas B. bifidum and B. longum subsp. infantis were not. Furthermore, it was found that the most predominant bifidobacterial species were B. longum subsp. longum and B. adolescentis. The results obtained revealed a high interindividual variability; however, a significant increase of B. longum subsp. infantis cell concentration was observed in the feces of volunteers after the wild blueberry drink treatment. This bifidobacterial group was shown to possess immunomodulatory abilities and to relieve symptoms and promote the regression of several gastrointestinal disorders. Thus, an increased cell concentration of B. longum subsp. infantis in the human gut could be considered of potential health benefit. In conclusion, wild blueberry consumption resulted in a specific bifidogenic effect that could positively affect certain populations of bifidobacteria with demonstrated health-promoting properties.