SYNAPSINS - MOSAICS OF SHARED AND INDIVIDUAL DOMAINS IN A FAMILY OF SYNAPTIC VESICLE PHOSPHOPROTEINS
SYNAPSINS - MOSAICS OF SHARED AND INDIVIDUAL DOMAINS IN A FAMILY OF SYNAPTIC VESICLE PHOSPHOPROTEINS
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DOI：
10.1126/science.2506642
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发表时间：
1989-09-29
期刊：
影响因子：
56.9
通讯作者：
GREENGARD, P
中科院分区：
文献类型：
--
作者：
SUDHOF, TC;CZERNIK, AJ;GREENGARD, P
突触蛋白是神经元的磷蛋白，其包覆突触囊泡，与细胞骨架结合，并且被认为在调节神经递质释放中起作用。分子克隆揭示了突触蛋白由四个同源蛋白组成的家族，其信使RNA是由两个基因的转录本的差异剪接产生的。每个突触蛋白都是由所有突触蛋白共有的同源氨基末端结构域和不同羧基末端结构域的不同组合组成的镶嵌体。免疫细胞化学研究表明，这四种突触蛋白都广泛分布于神经末梢，但它们的相对含量在不同种类的突触中有所不同。四种突触蛋白的结构多样性和差异分布表明，在不同的信号转导途径，调节神经递质释放在各种类型的神经元的整合中，每个共同和不同的作用。
Synapsins are neuronal phosphoproteins that coat synaptic vesicles, bind to the cytoskeleton, and are believed to function in the regulation of neurotransmitter release. Molecular cloning reveals that the synapsins comprise a family of four homologous proteins whose messenger RNA''s are generated by differential splicing of transcripts from two genes. Each synapsin is a mosaic composed of homologous amino-terminal domains common to all synapsins and different combinations of distinct carboxylterminal domains. Immunocytochemical studies demonstrated that all four synapsins are widely distributed in nerve terminals, but that their relative amounts vary among different kinds of synapses. The structural diversity and differential distribution of the four synapsins suggest common and different roles of each in the integration of distinct signal transduction pathways that modulate neurotransmitter release in various types of neurons.