Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer.
Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer.
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DOI：
10.3393/ac.2017.33.2.57
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发表时间：
2017-04
影响因子：
3.1
通讯作者：
Mohammadianpanah M
中科院分区：
文献类型：
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作者：
Hosseini S;Bananzadeh AM;Salek R;Zare-Bandamiri M;Kermani AT;Mohammadianpanah M
粘液腺癌约占所有结直肠癌的10%。本研究旨在探讨黏液组织学亚型对结直肠癌患者肿瘤预后的影响。本回顾性研究在两所大型三级大学医院进行。我们分析了2000年至2013年间接受治疗和随访的结直肠癌患者的特征、预后因素和生存率。1268例结直肠腺癌患者中有144例（11.4%）为粘液组织学亚型。本研究发现具有统计学意义的结果如下：与非粘液组织亚型相比，粘液组织亚型倾向于出现在更年轻的患者中，肿瘤大小更大，组织学分级更高，淋巴结分期更高，阳性淋巴结数量更多，神经周围浸润率更高。在单变量分析中，粘液亚型是无病和总生存的预后因素。在多因素分析中，原发肿瘤位置、淋巴结分期和淋巴血管浸润是影响局部控制率的独立预后因素。直肠肿瘤的位置、较高的疾病分期、肿瘤分级和存在淋巴血管侵犯对无病生存有负面影响，直肠肿瘤的位置、较高的疾病分期和存在淋巴血管侵犯对总生存有负面影响。结直肠癌患者黏液组织学亚型与某些不良病理特征相关；然而，它不是肿瘤预后的独立预后因素。
Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013. Totally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4%) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival. Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome.