Simultaneous estimation of chromophore concentration and scattering distributions from multiwavelength photoacoustic images
Simultaneous estimation of chromophore concentration and scattering distributions from multiwavelength photoacoustic images
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从多波长光声图像同时估计发色团浓度和散射分布
DOI：
10.1117/12.762924
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Cox B
中科院分区：
文献类型：
--
作者：
Cox B
在软组织的生物医学光声层析成像中，在短激发激光脉冲的吸收之后的初始声压分布被恢复为位置的函数。该初始压力分布与吸收的光能密度成比例，并且因此与组织光学系数相关（尽管是间接的）。当对含有几种吸收发色团（例如氧合血红蛋白和脱氧血红蛋白、水等）的软组织成像时，所关心的主要量是组织中每个点处的发色团浓度，而不是吸收的光能密度，吸收的光能密度与发色团浓度非线性相关，并且还取决于散射的分布。因此，估计发色团的浓度分布需要从一个（吸收能量密度）的测量中恢复两个未知函数（发色团浓度和散射分布）。对于在单个光波长处进行的测量，该问题具有非唯一性，并且在没有并入附加信息的情况下无法解决。一个模拟的例子在这里被用来证明，在原则上，通过使用多波长的数据，并将已知的波长依赖性的生色团的吸收和散射作为先验信息，生色团的浓度和散射的空间依赖性可以同时恢复。这一步开辟了使用多光谱光声断层成像的生理和分子成像的道路。
In biomedical photoacoustic tomography of soft tissue, the initial acoustic pressure distribution following the absorption of a short excitation laser pulse, is recovered as a function of position. This initial pressure distribution is proportional to the absorbed optical energy density, and is thus related (albeit indirectly) to the tissue optical coefficients. When imaging soft tissue which contains several absorbing chromophores (such as oxy- and deoxy-haemoglobin, water, etc.), the primary quantity of interest is the concentrations of the chromophores at each point in the tissue, and not the absorbed optical energy density, which is nonlinearly related to the chromophore concentrations, and also depends on the distribution of scattering. Estimating the distribution of the concentration of a chromophore therefore requires the recovery of two unknown functions (chromophore concentration and scattering distributions) from measurements of one (absorbed energy density). For measurements made at a single optical wavelength, this problem suffers from nonuniqueness, and cannot be solved without additional information being incorporated. A simulated example is used here to demonstrate that, in principle, by using multi-wavelength data and incorporating the known wavelength dependence of the chromophore absorption and the scattering as prior information, a chromophore concentration and spatial dependence of the scattering can be recovered simultaneously. This step opens the way to physiological and molecular imaging using multispectral photoacoustic tomography.
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影响因子：
6.1
作者：
WANG, LH;JACQUES, SL;ZHENG, LQ
通讯作者：
ZHENG, LQ
DOI：
10.1117/12.644806
发表时间：
2006
期刊：
2007 IEEE/ICME International Conference on Complex Medical Engineering
影响因子：
--
作者：
Benjamin T Cox;S. Arridge;P. Beard
通讯作者：
P. Beard
使用简单递归方法对散射介质中的吸收分布进行二维定量光声图像重建
DOI：
--
发表时间：
2006
期刊：
影响因子：
--
作者：
B. Cox;S R Arridge;K. P. Köstli;P. Beard
通讯作者：
P. Beard
影响因子：
1.9
作者：
Corlu, A;Choe, R;Yodh, AG
通讯作者：
Yodh, AG