Circulating angiogenic factors in singleton vs multiple-gestation pregnancies
Circulating angiogenic factors in singleton vs multiple-gestation pregnancies
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DOI：
10.1016/j.ajog.2007.08.042
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发表时间：
2008-02-01
影响因子：
9.8
通讯作者：
Meyer, Bruce A.
中科院分区：
文献类型：
--
作者：
Maynard, Sharon E.;Simas, Tiffany A. Moore;Meyer, Bruce A.
目的：胎盘可溶性膜样酪氨酸激酶-1可能参与子痫前期的发病机制。在这里，我们描述了多胎妊娠妇女血清血管生成因子水平的变化，这是子痫前期的一个主要危险因素。研究设计：我们收集了101例妊娠22 - 36周子痫前期高危孕妇的血清样本。采用酶联免疫吸附法测定可溶性膜样酪氨酸激酶-1和胎盘生长因子。有先兆子痫或妊娠期高血压的妇女被排除在外。结果：多胎妊娠（n = 20）与高危单胎妊娠（n = 81）相比，多胎妊娠（n = 20）的母体可溶性纤维样酪氨酸激酶-1较高。31周前多胎和高危单胎的胎盘生长因子明显高于高危单胎，27周后多胎和高危单胎的可溶性类酪氨酸激酶-1/胎盘生长因子比值明显高于高危单胎。结论：循环血管生成因子的改变存在于多胎妊娠妇女中，并可能导致该人群子痫前期风险升高。
OBJECTIVE: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor.STUDY DESIGN: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded.RESULTS: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high- risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high- risk singletons after 27 weeks.CONCLUSION: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher pre-eclampsia risk in this population.